Xinbin Chen

image of Xinbin Chen


Internal Medicine - Medicine
VM Surgical & Radiological Sci

Offices and Labs

2128A Tupper Hall
+1 530 754 8404


1991 PhD Microbiology Michigan State University
1985 MS Infectious Diseases Nanjing Agricultural University in China
1982 BVSc Veterinary Medicine Anhui Agricultural University in China


Distinguished Teaching Award, Medical College of Georgia, 2000

Department and Center Affiliations

Surgical and Radiological Sciences
Internal Medicine
UCD Cancer Center
Center for Comparative Oncology


Member of the Editorial Board, Journal of Biological Chemistry, 2007-2012
Member of the Editorial Board, Cancer Biology and Therapy, 2006-2009
American Association for Cancer Research
American Society of Biochemistry and Molecular Biology
American Association for Microbiology

CBS Grad Group Affiliations

Biochemistry, Molecular, Cellular and Developmental Biology


Tupper 2117-2119
  • A. Scoumanne, Ph.D.; W. Yan, M.D. and Ph.D.; S-J Cho, Ph.D.; Y. Zhang, Ph.D.; A Rossi, Ph.D.; Y-S Jung, Ph.D.; X. Chen, M.D. and Ph.D.; S. Y. Yeo; Y. Qian; J. Zhang, Ph.D.

Teaching Interests

Cell Cycle, Tumor Suppressor, Oncogene, Signal Transduction, Transcriptional Regulation


5/21/2010 9:26:34 AM
  • (Selected from ~75 publications)
  • Harm, K and X. Chen. 2005. The C-terminus is a cell fate determinant of the p53 family proteins. Mol. Cell. Biol. 25:2014-2030.
  • Liu, G. and X. Chen. 2006. DNA polymerase eta, the product of the Xeroderma Pigmentosum Variant gene and a target of p53, modulates the DNA damage checkpoint and p53 activation. Mol. Cell. Biol. 26(4):1398-1413.
  • Helton, E. S., J. Zhu, and X. Chen. 2006. The unique DN residues, the PXXP motif, and the PPXY motif are required for the transcriptional activity of the DN variant of p63. J. Biol. Chem. 281(5): 2533-2542.
  • Jung, E. J., G. Liu, W. Zhou, and X. Chen. 2006. Myosin VI is a mediator of the p53-dependent cell survival pathway. Mol. Cell. Biol. 26: 2175-2186.
  • Scoumanne, A. and X. Chen. 2006. ECT2, a guanine nucleotide-exchange factor for Rho GTPases and a target of p53, is required for cell cycle transition from G1 to S. Cancer Research 66: 6271-6279.
  • Shu, L. W. Yan, and X. Chen. 2006. RNPC1, a RNA-binding protein and a target of the p53 family, is required for maintaining the stability of the basal and stress-induced p21 transcript. Genes & Dev. 20: 2961-2972.
  • Harms, K. and X. Chen. 2007. Histone deacetylase 2 modulates p53 transcriptional activities through regulation of p53-DNA binding activity. Cancer Res. 67: 3145-3152.
  • Zhang, J. and X. Chen. 2007. DNp73 modulates NGF-mediated neuronal differentiation through repression of TrkA. Mol. Cell. Biol. 27: 3868-3880.
  • Scoumanne, A. and X. Chen. 2007. The Lysine-Specific Demethylase 1 is required for cell proliferation in both p53-dependent and -independent manners. J. Biol. Chem. 282: 15471-15475.