Bruce Draper

image of Bruce Draper

Associate Professor

Departments

Molecular & Cellular Biology

Offices and Labs

Life Science 3129
(530) 752-0833

Degrees

1995 PhD Zoology University of Washington
1988 BA Biochemistry and Cellular Biology University of California, San Diego

Research Interests

Germline stem cells

We study mechanisms that regulate the development and function of germline stem cell in zebrafish, with a main focus on female germline stem cells. We study factors that function within the stem cells, as well as those that are required for the development of the somatic gonad, the germ cell niche.

Sex determination and maintenance of the adult sexual phenotype

While zebrafish do not switch sex as adults, our lab has recently discovered that maintenance of the adult female sexual phenotype is an active process that requires continuous input from germ cells, as reduction of germ cell numbers in an adult female results in female-to-male sex reversal. Our current research is focused on determining what signal is produced by the germ cells and how it influences the developmental state of the somatic gonad.

Awards

Damon Runyon Cancer Research Foundation Fellowship (1997-2000)

Department and Center Affiliations

Molecular and Cellular Biology

ProfessionalSocieties

Society for Developmental Biology
American Association for the Advancement of Science

CBS Grad Group Affiliations

Integrated Genetics and Genomics
Biochemistry, Molecular, Cellular and Developmental Biology

Specialties / Focus

Biochemistry, Molecular, Cellular and Developmental Biology
  • Development
  • Reproductive Biology

Publications

1/28/2013 9:56:21 AM
  • Dranow, D.B., Tucker, R.P. and Draper, B.W. Germ cells are required to maintain a stable sexual phenotype in adult zebrafish. Dev. Biol. (in press).
  • Beer, RL and Draper, B.W. (2013) nanos3 maintains germline stem cells and expression of the conserved germline stem cell gene nanos2 in the zebrafish ovary. Dev. Biol.374, 308-318.
  • Huang, H.Y., Houwing, S., Kaaij, L.J., Meppelink, A., Redl, S., Gauci, S., Vos, H., Draper, B.W., Moens, C.B., Burgering, B.M., Ladurner, P., Krijgsveld, J., Berezikov, E., and Ketting, R.F. (2011) Tdrd1 acts as a molecular scaffold for Piwi proteins and piRNA targets in zebrafish. EMBO J. 30(16): 3298-308.
  • Wong, A.C., Draper, B.W., and Van Eenennaam, A.L. (2011) FLPe functions in zebrafish embryos. Transgenic. Res. 20(2): 409-415.
  • Leu, D.H. and Draper, B.W. (2010) The ziwi promoter drives germline-specific expression in zebrafish. Dev. Dyn. 239, 2714-2721.
  • Houwing, S., Kamminga, L. M., Berezikov, E., Cronembold, D. Girard, A., van der Elst, H., Filippov, D. V., Blaser, H., Raz, E., Moens, C. B., Plasterk, R. H., Hannon, G. J., Draper, B. W., Ketting, R. F. (2007) A role for Piwi and piRNAs in germ cell maintenance and transposon silencing in zebrafish. Cell (in press).
  • Draper, B. W., McCallum, C. M. and Moens, C. B. (2007) nanos1 is required to maintain oocyte production in adult zebrafish. Dev. Bio. (in press).
  • Draper, B.W., McCallum, C.M., Stout, J.L., Slade, A.J. and Moens, C.B. (2004) A High-Throughput method for identifying ENU-induced point mutations in zebrafish. Method Cell Biol. 77, 91-112.
  • Draper, B.W., Stock, D. W. and Kimmel, C.B. (2003). Zebrafish fgf24 functions with fgf8 to promote posterior mesoderm development and is required for pectoral fin formation. Development 130, 4639-4654.

Labs

Draper Lab website
  • Daniel Dranow (BMCDB) Dena Leerberg (BMCDB) Yana Blokhina (GGG)

Teaching Interests

Developmental Biology, Genetics, Genomics

Courses

BIS 101 Genetics
MCB 251 Molecular Mechanisms in Early Development