Paramita Ghosh

image of Paramita Ghosh

Associate Professor

Departments

Urology - Medicine
Biochemistry and Molecular Medicine

Offices and Labs

Rm 2200A, Research III, UC Davis Medical Center
+1 916 734 7805
Bldg 722, Rm 121, VA Northern California, Mather, CA
+1 916 843 9336
+1 916 275 3246

Degrees

1994 PhD Chemistry Rensselaer Polytechnic Institute
1989 MS Physics Jadavpur University, Calcutta, INDIA
1987 BS Physics Jadavpur University, Calcutta, INDIA

Research Interests

Signal Transduction Pathways in Prostate Cancer

The pathways we study include the phosphatidylinositol 3-kinase (PI3K)/Akt pathway, the Ras/Raf/MEK/MAPK pathway and other signaling pathways both upstream and downstream of these. This includes the mammalian target of rapamycin (mTOR) pathway, and signaling by the epidermal growth factor receptor (EGFR), related receptor tyrosine kinases ErbB2 and ErbB3.

Awards

2000 WICR Young Investigator Scholar Award. American Association for Cancer Research
1997-1999 NIH Postdoctoral Training Award. Department of Pathology, University of Texas Health Science Center at San Antonio, TX.
1989-1994 Tuition Scholarship and Graduate Assistantship. Rensselaer Polytechnic Institute, Troy, NY
1989 Gold Medal for Excellence, Master of Science. Department of Physics, Jadavpur University, Calcutta 700032, India
1989 S.N. Bose Medal for best academic achievement. Department of Physics, Jadavpur University, Calcutta 700032, India.
1983-1989 National Science Scholarship. University Grants Commission, Government of India
2006 UC Davis Academic Federation Travel Award
2006 Best Poster Award. International Symposium on Hormonal Carcinogenesis, Montpellier, France

Department and Center Affiliations

Department of Urology, School of Medicine
UC Davis Cancer Center
Department of Biochemistry and Molecular Medicine

ProfessionalSocieties

American Association for Cancer Research
Society of Basic Urological Research
American Association for the Advancement of Science
American Urological Association

CBS Grad Group Affiliations

Biochemistry, Molecular, Cellular and Developmental Biology
Integrated Genetics and Genomics

Specialties / Focus

Biochemistry, Molecular, Cellular and Developmental Biology
  • Molecular Medicine
  • Signal Transduction and Gene Regulation
Integrated Genetics and Genomics
  • Human Genetics

Graduate Groups not Housed in CBS

Pharmacology and Toxicology Graduate Group
Comparative Pathology

Publications

1/27/2012 11:54:29 AM
  • Chen L, Mooso BA, Jathal MK, Madhav A, Johnson SD, van Spyk E, Mikhailova M, Zierenberg-Ripoll A, Xue L, Vinall RL, deVere White RW, Ghosh PM. Dual EGFR/HER2 inhibition sensitizes prostate cancer cells to androgen withdrawal by suppressing ErbB3. Clin Cancer Res. 2011 Oct 1; 17 (19):6218-28.
  • Vinall RL, Mahaffey CM, Davis RR, Luo Z, Gandour-Edwards R, Ghosh PM, Tepper CG, de Vere White RW. Dual blockade of PKA and NF-B inhibits H2 relaxin-mediated castrate-resistant growth of prostate cancer sublines and induces apoptosis. Horm Cancer. 2011 Aug; 2 (4):224-38. PubMed PMID: 21789713.
  • Jathal MK, Chen L, Mudryj M, Ghosh PM. Targeting ErbB3: the New RTK(id) on the Prostate Cancer Block. Immunol Endocr Metab Agents Med Chem. 2011 Jun; 11 (2):131-149. PubMed PMID: 21603064
  • Roy M, Kung HJ, Ghosh PM. Statins and prostate cancer: role of cholesterol inhibition vs prevention of small GTP-binding proteins. Am J Cancer Res. 2011; 1 (4):542-61. PubMed PMID: 21984972.
  • Ghosh PM. What controls PTEN and what it controls (in prostate cancer). Asian J Androl. 2011 Sep 26; PubMed PMID: 21946231.
  • Chen H, Libertini SJ, Wang Y, Kung HJ, Ghosh P, Mudryj M. ERK regulates calpain 2-induced androgen receptor proteolysis in CWR22 relapsed prostate tumor cell lines. J Biol Chem. Jan 22;285(4):2368-74. 2010
  • Chen, L, Lu, X.-H., Shi, X.-B., R., deVere White, RW, Carraway, K.L. III and Ghosh, PM. Nrdp1-mediated regulation of ErbB3 expression by the androgen receptor in androgen-dependent but not castrate–resistant prostate cancer cells. Cancer Research. 70(14):5994-6003, 2010.
  • Mooso, B., Madhav, A. Johnson, S.D., Roy, M., Moore, M.E., Moy, C., Loredo, Mehta, R.G., Vaughan, A.T.M. and Ghosh, P.M. Androgen Receptor regulation of Vitamin D receptor in response of castration-resistant prostate cancer cells to 1α-Hydroxyvitamin D5 – a calcitriol analog. Genes and Cancer, 2010. Nov 16;1(9):927-940.
  • Chen, H., Libertini, S.J., George, M., Dandekar, S., Tepper, C.G., Al-Bataina, B., Kung, H.-J., Ghosh, P.M., Mudryj, M. Genome-wide analysis of androgen receptor binding and gene regulation in two CWR22-derived prostate cancer cell lines. Endocrine-related cancers. 2010. Oct 5;17(4):857-73.
  • Khan, IH, Zhao, J, Ghosh, PM, Ziman, M, Sweeney, C, Kung, HJ and Luciw, PA. Activation and Dimerization of Receptor Tyrosine Kinases (ErbB Family) in Breast Cancer Cells Analyzed by Multiplex Microbead Suspension Array. ASSAY and Drug Development Technologies. Feb;8(1):27-36. 2010
  • Ghosh P, Qiu Y, Wang LY and Kung HJ. Tyrosine Kinome Profiling: Oncogenic Mutations and Therapeutic Targeting in Cancer ** IN PRESS ** 2010.
  • Bedolla, RG, Asuncion, A, Chamie, K, Siddiqui, S, Troyer, DA, Mehra, R, Siddiqui, J, Chinnaiyan, AM, deVereWhite, RW, and Ghosh, PM. Nuclear vs Cytoplasmic localization of Filamin A in Prostate Cancer: Immunohistochemical Correlation with Metastases. Clinical Cancer Research, 15(3): 788-796. 2009.
  • Chamie, K, Ghosh, PM, Koppie, TM, Romero, V, Troppmann, C,and deVere White, RW. The effect of sirolimus on PSA kinetics in male renal transplant recipients without prostate cancer. American Journal of Transplantation, 8(12): 2668-2673. 2008.
  • Wang, Y, Mikhailova, M, deVere White, RW, and Ghosh, PM. Regulation of androgen receptor transcriptional activity by rapamycin. Oncogene, 27(56): 7106-7117. 2008
  • Kamat, A., Ghosh, PM, Glover, RL, Zhu, B, Yeh, CK, Choudhury, GG and Katz, MS. Reduced Expression of Epidermal Growth Factor Receptors in. Journal of Gerontology, 63(7): 683-692. 2008
  • Mikhailova, M., Wang, Y., Bedolla, R.G., Lu, X.H., Kreisberg, J.I. and Ghosh, P.M.: AKT Regulates Androgen Receptor-dependent Growth and PSA Expression in Prostate Cancer, Adv Exp Med Biol., Vol. 617, pp. 397-405. 2008.
  • Wang, Y., Kreisberg, J.I. and Ghosh, P.M. Cross-talk between the Androgen Receptor and the Phosphatidylinositol 3-kinase/Akt pathway in Androgen-Independent Prostate Cancer. Current Cancer Drug Targets. 7: 591-604. 2007
  • Shi, X.-B., Xue, L. Tepper, C.G., Gandour-Edwards, R., Ghosh, P., Kung, H.J. and deVere White, R.W. . The oncogenic potential of a prostate cancer-derived androgen receptor mutant. The Prostate, 67(6): 591-602. 2007.
  • Bedolla R, Prihoda TJ, Kreisberg JI, Malik SN, Krishnegowda NK, Troyer DA, Ghosh PM. Determining risk of biochemical recurrence in prostate cancer by immunohistochemical detection of PTEN expression and Akt activation. Clin. Cancer Res., 13(13): 3860-3867. 2007
  • Wang, Y., Kreisberg, J.I., Bedolla, R., Mikhailova, M., deVere White, R.W. and Ghosh, P.M. A 90 kDa fragment of filamin A promotes Casodex-induced growth inhibition in Casodex-resistant androgen receptor positive C4-2 prostate cancer cells. Oncogene. 2007.
  • Margarita Mikhailova, Yu Wang, Roble Bedolla, Xiao-Hua Lu, Jeffrey I. Kreisberg, and Paramita M. Ghosh : AKT Regulates Androgen Receptor-dependent Growth and PSA Expression in Prostate Cancer, Jonathan Li, (ed), Hormonal Carcinogenesis, Vol. 5, Springer Verlag, New York. 2007.
  • Vinall, R.L., Hwa, K., Ghosh, P., Pan, C-X., Lara, P.N. Jr. and deVere White, R.W. Combination Treatment Of Prostate Cancer Cell Lines With Bioactive Soy Isoflavones (GCP) And Perifosine Causes Increased Growth Arrest And/Or Apoptosis. Clinical Cancer Research. 13: 6204-6216. 2007.
  • Wang, Y., Kreisberg, J.I. and Ghosh, P.M. Cross-talk between the Androgen Receptor and the Phosphatidylinositol 3-kinase/Akt pathway in Androgen-Independent Prostate Cancer. Current Cancer Drug Targets. 7: 591-604. 2007
  • Vinall, R.L., Hwa, K., Ghosh, P., Pan, C-X., Lara, P.N. Jr. and deVere White, R.W. Combination Treatment Of Prostate Cancer Cell Lines With Bioactive Soy Isoflavones (GCP) And Perifosine Causes Increased Growth Arrest And/Or Apoptosis. Clinical Cancer Res., 13: 6204-6216, 2007
  • Ghosh, P.M., Malik, S.N., Prihoda, T.J., Bedolla, R.G., Wang, Y., Troyer, D.A. and Kreisberg, J.I. Akt mediates proliferation via both androgen-dependent and independent pathways in prostate cancer. Endocr Relat Cancer. Mar;12(1):119 34. 2005
  • Yeh, C. K.**, Ghosh, P.M.**, Liu, Q., Zhang, B. X., and Katz, M.S. Activation of Mitogen-activated Protein Kinase Mediates Isoproterenol-induced Salivary Cell Growth. Am J Physiol Cell Physiol. 288(6):C1357-C1366. 2005
  • Ghosh, P.M., Bedolla, R., Thomas, C.A. and Kreisberg, JI. Role of Protein kinase C in Arginine Vasopressin-stimulated mesangial cell proliferation. J. Cell. Biochem., 2004; 91(6):1109-29.
  • Kreisberg, J.I., Malik, S.N., Prihoda, T.J., Bedolla, R.G., Troyer, D.A. Kreisberg, S. and Ghosh, P.M. Expression of phospho-AKT (Ser 473) is an excellent predictor of Poor Clinical Outcome in Prostate Cancer. Cancer Res. Aug 1;64(15):5232-6. 2004
  • Ghosh, P.M., Malik, S. N., Bedolla, R. and Kreisberg, J.I. Akt in Prostate Cancer: Possible Role in Androgen-Independence. Current Drug Metabolism, 4(6):487-496. 2003
  • Ghosh PM, Bedolla R, Mikhailova M, and Kreisberg JI. RhoA-Dependent Murine Prostate Cancer Cell Proliferation and Apoptosis: Role of PKCzeta. Cancer Res. 62(9):2630-6. 2002
  • Malik, S.N., Brattain, M.G., Ghosh, P.M., Troyer, D.A., Prihoda, T., Bedolla, R. and Kreisberg, J.I. Immunohistochemical Demonstration of phospho-Akt in High Gleason Grade Prostate Cancer. Clinical Cancer Res. 8(4):1168-71. 2002
  • Sawhney RS, Guo-Hao K, Humphrey LE, Ghosh P, Kreisberg JI, Brattain MG: Differences in sensitivity of biological functions mediated by epidermal growth factor receptor activation with respect to endogenous and exogenous ligands. J Biol Chem 277: 75-86. 2002
  • Ghosh, P.M., Mikhailova, M., Bedolla, R. and Kreisberg, J.I. Arginine Vasopressin Stimulates Mesangial Cell Proliferation by Activating the Epidermal Growth Factor Receptor. Am. J. Physiol- Renal Physiology. 280(6):F972-979. 2001
  • Ghosh-Choudhury, N., Ghosh-Choudhury, G., Celeste, A., Ghosh, P.M., Moyer, M.L., Abboud, S.L., and Kreisberg, J.I. Bone Morphogenic Protein-2 induces cyclin kinase inhibitor p21 and hypophosphorylation of retinoblastoma protein in estradiol treated MCF- human breast cancer cells. Biochim. Biophys. Acta 1497:186-196. 2000
  • Ghosh, P.M., M. Moyer and J.I. Kreisberg. Effect of cyclin E overexpression on lovastatin-induced G1 arrest and RhoA inactivation in NIH3T3 cells. J. Cell. Biochem. 74: 532  543. 1999
  • Ghosh, P.M., G.E. Mott, M.L. Stapleton, N. Ghosh-Choudhury and J.I. Kreisberg. Role of RhoA and actin stress fiber formation in the proliferation of a mouse prostate cancer cell line. Oncogene. 18: 4120-4130. 1999
  • Ghosh, P., G.E. Mott, N. Ghosh-Choudhury, R.A. Radnik, M.L. Stapleton, J.J. Ghidoni and J.I. Kreisberg. Lovastatin induces apoptosis by inhibiting mitotic and post-mitotic events in cultured mesangial cells. Biochim. Biophys. Acta. 1359: 13-24. 1997
  • Klebe, R.J., A. Grant, G. Grant and P. Ghosh. 1995. Cyclic-AMP deficient MDCK cells from tubules. J. Cell Biochem. 59:453-462. 1995
  • Klebe, R.J., C.A. Thomas, G.M. Grant, A. Grant and P. Ghosh. Cytoscription: Computer-controlled micropositioning of cell adhesion proteins. J. Tissue Culture Methods. 16:189-192. 1994
  • Ghosh, P.M., C.R. Keese and I. Giaever. Morphological response of mammalian cells to pulsed AC fields. Bioelectrochem. Bioenerg. 33:121-133. 1994
  • Ghosh, P.M., C.R. Keese and I. Giaever. Monitoring Electropermeabilization in the Plasma Membrane of Adherent Mammalian Cells. Biophys. J. 64: 1602-1609. 1993
  • Mitra, P., C.R. Keese and I. Giaever. Electrical Measurements can be used to Monitor the Attachment and Spreading of Cells in Tissue Culture. Biotechniques. 11: 504-510. 1991

Labs

Postdoctoral Fellows website
  • Salma Siddiqui; Sheetal Singh
Graduate Students
  • Rosalinda Savoy; Leandro D'Abronzo; Maitreyee Jathal
Research Associate
  • Benjamin Mooso; Ryan Beggs; Mohana Roy

Teaching Interests

Cell and Molecular Biology Biochemistry

Courses

BCM 410B Cell Biology and Metabolism (Winter)
BCM 410A Molecular and Cell Biology (Fall)
MCB 257 Cell Prolif Cancer Genes (Fall)