David Pleasure

image of David Pleasure



Director, Institute for Pediatric Regenerative Medicine
Neurology - Medicine

Offices and Labs

Room 602A, Shriners Hospital

Profile Introduction

Our laboratory uses cell and molecular biological techniques to study the development and regeneration of the nervous system. Our current focus is on mechanisms of death and regeneration of oligodendroglia, the myelin-forming cells of the central nervous system, that take place during experimental autoimmune encephalomyelitis and in leukodystrophies.


63 MD Medicine P&S, Columbia
59 BA History Yale

Research Interests

Pathogenesis of multiple sclerosis, leukodystrophies, and cerebral palsy

Genetic and epigenetic regulation of neural stem cell lineages


Phi Beta Kappa Yale, Alpha Omega Alpha P&S Columbia
Jacob Javits Neuroscience Award, NINDS, NIH 1992-1999
Fellow, American Association for the Advancement of Science, 2005
Listed in "Best Doctors in America" 1993-2015
Phi Beta Kappa Yale, Alpha Omega Alpha P&S Columbia, NIH RO1 NS025044 funded through 6/2012 (year 27); 2011, Elected Honorary Member, American Neurological Association; 2011 Distinguished Professor UC Davis

Department and Center Affiliations

Professor, Neurology and Pediatrics, UC Davis School of Medicine
Director, Research, Shriners Hospitals for Children Northern California
Director, UC Davis/Shriners Institute for Pediatric Regenerative Medicine
Director, UC Davis/Shriners Institute for Pediatric Regenerative Medicine (IPRM)


Fellow, American Academy of Neurology
Honorary Member, American Neurological Association
Member, Society for Neuroscience

CBS Grad Group Affiliations

Biochemistry, Molecular, Cellular and Developmental Biology

Specialties / Focus

Biochemistry, Molecular, Cellular and Developmental Biology
  • Molecular Medicine
  • Cellular Responses to Toxins and Stress

Graduate Groups not Housed in CBS

Comparative Pathology, Clinical Research
Comparative Pathology


Institute for Pediatric Regenerative Medicine - 6th floor Shriners Hospital
  • Currently, 3 postdoctoral fellows, 4 graduate students (2 from Immunology, 1 from Comparative Pathology, and 1 from BMCDB), and 2 research technicians

Teaching Interests

Clinical adult and pediatric neurology
Mechanisms of glial diseases

Personal Interests

jogging, classical music


8/31/2015 11:27:13 AM
  • Guo, Lang, Sohn, Hammond, Chang, Pleasure (2015) Canonical Wnt signaling in the oligodendroglial lineage—puzzles remain.  Glia 63:1671-1693, 2015 (PMID: 25782433).

  • Guo, Bannerman, Mills Ko, Miers, Xu, Burns, Li, Freeman, McDonough, Pleasure (2015) Ablation of N-acetyl-L-aspartate synthesis prevents leukodystrophy in a murine model of Canavan disease.  Ann Neurol 77:884-888 (PMID: 25712859).

  •  Hammond, Lang, Maeda, Pleasure, Angus-Hill, Xu, Deng, Guo (2015)  The Wnt effector TCF7l2 positively regulates oligodendrocyte differentiation in a manner independent of Wnt/beta-catenin signaling. J Neurosci 35:5007-5022 (PMID: 25810530).

  • Sohn, Orosco, Guo, Chung, Bannerman, Mills Ko, Zarbalis, Deng, Pleasure (2015) The subventricular zone continues to generate corpus callosum and rostral migratory stream astroglia in normal adult mice.  J Neurosci 35:3756-3763 (PMID: 25740506).

  • Itoh, Horiuchi, Ikeda, Xu, Bannerman, Pleasure, Penninger, Tournier, Itoh (2014) ZPK/DLK and MKK4 form the critical gateway to axotomy-induced motoneuron death in neonates.  J Neurosci 34:10729-10742 (PMID: 25100604).

  • Moreno, Bannerman, Ma, Guo, Miers, Soulika, Pleasure (2014) Conditional ablation of astroglial CCL2 suppresses CNS accumulation of M1 macrophages and preserves axons in mice with MOG peptide EAE.  J Neurosci 34:8175-8185 (PMID: 24920622).

  • Chetty, Friedman, Kirby, Mirescu, Taravosh-Lahn, Guo, Krupik, Nicholas, Geraghty, Krishnamurthy, Tsai, Covarrubias, Wong, Francis, Sapolsky, Palmer, Pleasure, Kaufer (2014) Stress and glucocorticoids promote oligodendrogenesis in the adult hippocampus.  Mol Psychiatry 19:1275-1283 (PMID: 24514565).

  • Orosco, Ross, Cates, Scott, Wu, Sohn, Pleasure (D), Pleasure (S), Adamopoulos, Zarbalis (2014) Loss of Wdfy3 in mice alters cerebral cortical neurogenesis reflecting aspects of the autism pathology.  Nature Commun 5:4692 (PMID: 25198012).

  • Chen, Jiang, Xue, Peterson, Tran, McCann, Parast, Li, Pleasure, Laurent, Loring, Liu, Deng (2014) Role of astroglia in Down's syndrome revealed by patient-derived human-induced pluripotent stem cells.  Nature Commun 5:4430 (PMID: 25034944).

  • Lang, Maeda, Bannerman, Jie, Xu, Horiuchi, Pleasure*, Guo* (2013) Adenomatous polyposis coli regulates oligodendroglial differentiation.  J Neurosci 33:3113-3130 (PMID: 23407966).  *co-senior authors.

  • Jiang, Chen, Wang, Chechneva, Chung, Rao, Pleasure, Liu, Zhang, Deng (2013) hESC-derived Olig2+ progenitors generate a subtype of astroglia with protective effects against ischaemic brain injury.  Nature Commun 4:2196 (PMID: 23880652).

  • Sohn, Selvaraj, Wakayama, Orosco, Lee, Crawford, Guo, Lang, Horiuchi, Zarbalis, Itoh, Deng, Pleasure (2012) PEDF is a novel oligodendrogenic morphogen acting on the adult SVZ and corpus callosum.  J Neurosci 32:12152-12164 (PMID: 22933798).

  • Guo, Maeda, Ma, Delgado, Sohn, Miers, Mills Ko, Bannerman, Xu, Wang, Zhou, Takebayashi, Pleasure (2011) Macroglial plasticity and the origins of reactive astroglia in experimental autoimmune encephalomyelitis. J Neurosci 31:11914-11928 (PMID: 21849552).

  • Itoh, Horiuchi, Wakayama, Xu, Bannerman, Pleasure, Itoh  (2011) ZPK/DLK, a mitogen-activated protein kinase kinase kinase, is a critical mediator of programmed cell death of motoneurons. J Neurosci 31:7223-7228 (PMID:  21593306).

  • Guo, Maeda, Ma, Xu, Horiuchi, Miers, Vaccarino, Pleasure (2010) Pyramidal neurons are generated from oligodendroglial progenitor cells in adult piriform cortex. J Neurosci 30:12036-12049 (PMID: 20826667).

  • Soulika, Lee, McCauley, Miers, Bannerman, Pleasure (2009) Initiation and progression of axonopathy in experimental autoimmune encephalomyelitis. J Neurosci 29:14965-14979 (PMID: 19940192).

  • Guo, Ma, McCauley, Bannerman, Pleasure (2009) Early postnatal proteolipid promoter-expressing progenitors produce multilineage cells in vivo. J Neurosci 29:7256-7270 (PMID: 19494148).

  • Feldman, Horiuchi, Keachie, McCauley, Bannerman, Itoh, Itoh, Pleasure (2008) Characterization of acid-sensing ion channel expression in oligodendrocyte-lineage cells. Glia 56:1238-1249 (PMID: 18452213).

  • Bannerman, Hahn, Gallo, Pleasure (2007) Astrogliosis in EAE: derivation from radial glia, and relationships to oligodendroglia. Glia 55:57-64 (PMID: 17009237).

  • Bannerman, Hahn, Ramirez, Morley, Bonnemann, Yu, Zhang, Rostami, Pleasure (2005) Motor neuron pathology in experimental autoimmune encephalomyelitis: studies in THY1-YFP transgenic mice. Brain 128:1877-1886 (PMID: 15901645).