Gang-Yu Liu

image of Gang-Yu Liu

Professor

Departments

Chemistry

Offices and Labs

Chemistry Building / 322
+1 530 754 9678

Profile Introduction

Professor Liu’s overall research objective focuses on the development of nanotechnology and potential applications to bioanalytical chemistry. One important aspect of the research is the design and engineering of nanostructures which position bioreceptors and chemical reaction sites on surfaces with high precision. The exquisite precision attainable by the nanolithographic methods developed allows complex multivalent interactions typical of bio-recognition to be controlled by varying the separation and local environment of the binding sites. Current projects include: (1) development of state-of-the-art imaging tools for high-resolution imaging of ligands, DNA, proteins and cells; (2) advanced methodologies for production of arrays of nanostructures; (3) single-cell imaging and mechanics; (4) using nanostructures of antibodies produced to investigate hypersensitivity reaction or allergy; (5) using nanostructures of ligands for study of the initial HIV infection of human T-cells; and (6) using nanostructures of ligands for the investigation of cancer cell signaling.

Degrees

1992 PhD Chemistry Princeton University

Research Interests

Advanced nanotechnology for biophysical research and development

Awards

1986-1987 CGP (Chemistry Graduate Program) Fellowship, Princeton University
1990-1991 Harold W. Dodds Honorific Fellowship granted by Princeton University
1992-1994 Miller Research Fellowship by the Miller Institute for Basic Research in Science, UC Berkeley
1994-1999 Camille and Henry Dreyfus New Faculty Award
1996-1998 Arnold and Mable Beckman Young Investigator Award
1997-2001 NSF-CAREER Award, granted by National Science Foundation
2000 Outstanding Scholarly Achievements Award, Wayne State University
2000-2001 Career Development Chair Award, Wayne State University
2007 AAAS Fellow
2010 ACS Fellow

Department and Center Affiliations

Chemistry Department
NEAT ORU
Biophysics Graduate Group
UCDMC Cancer Center

ProfessionalSocieties

ACS
APS
AVS
Biophys Soc.
ASCB
AAAS
PADI

CBS Grad Group Affiliations

Biophysics

Graduate Groups not Housed in CBS

Chemistry

Labs

Chemistry Building Laboratories 11, 12, 25, 31 and Annex 0480 website

Teaching Interests

High resolution imaging and nanotechnology; analytical chemistry, physical chemistry, general chemistry

Courses

CHE 2C General Chemistry
CHE 241E High-Resolution Imaging and Nanotechnology
CHE 115 Analytical Chemistry
CHE 110C Physical Chemistry

Publications

2/19/2015 2:14:37 PM
  • 2002       Liu, G.Y. and N.A. Amro.  Positioning Protein Molecules on Surfaces: A Nanoengineering Approach to Supramolecular Chemistry.  PNAS, 99, 5165-5170.

  • 2006       Yu, J.; Y.H. Tan, X. Li, P.K. Kuo and G.Y. Liu.  A Nanoengineering Approach to Regulate the Lateral Heterogeneity of Self-Assembled Monolayers.  J. Am. Chem.  Soc. 128(35), 11574-11581.

  • 2009       Deng, Z., T. Zink, H. Chen, D. Walters, F.-T. Liu and G.-Y. Liu.  Impact of Actin Rearrangement and Degranulation on the Membrane Structure of Primary Mast Cells:  A Combined Atomic Force and Laser Scanning Confocal Microscopy Investigation. Biophysical Journal, 96, 1629-1639.

  • 2010       Lulevich, V., C. Zimmer, H.S. Hong, L.W. Jin and G.Y. Liu. Single Cell Mechanics Provides a Sensitive and Quantitative Means for Probing Aβ Peptide - Neuronal Cell Interactions. PANS, 107(31), 13872–13877.

  • 2010       Liu, G.YDriving the “Structure-Property-Function” Paradigm of Protein and DNA via Physical Chemistry.  JPC Lett., 1(22), 3305.

  • 2011       Deng, Z., I.C. Weng, J.R. Li, H.Y. Chen, T.T. Liu and G.Y. Liu.   Engineered Nanostructures of Antigen Provide an Effective Means for Regulating Mast Cell Activation. ACS Nano, 5(11), 8672–8683.

  • 2011       Fleming, C.J., N.N. Yin, S.L. Riechers, G. Chu and G.Y. Liu.  High-Resolution Imaging of the Intramolecular Structure of Indomethacin-Carrying Dendrimers by Scanning Tunneling Microscopy. ACS Nano, 2011, 5(3), 1685-1692.

  • 2011       Mullen, T.J., M. Zhang, W. Feng, R.J. El-khouri, L.d. Sun, C.H. Yan, T.E. Patten and G.Y. Liu.  Fabrication and Characterization of Rare-Earth-Doped Nanostructures on Surfaces.  ACS Nano, 5(8), 6539–6545.

  • 2012       Lin, W., J-R. Li and G.Y. Liu.   Near-Field Scanning Optical Microscopy Enables Direct Observation of Moiré Effects at Nanometer Scale Levels.  ACS Nano, 6(10), 9141-9149.

  • 2014       Zimmer, C.C., Y.X. Liu, J.T. Morgan, G. Yang, K-H. Wang, I.M. Kennedy, A.I. Barakat and G.Y. LiuNew Approach to Investigate the Cytotoxicity of Nanomaterials Using Single Cell Mechanics.  J. Phys. Chem. B, 118, 1246-1255.

  • 2014       Du, C., M. Zhang, J-W. Jang, Y. Liu, G.Y. Liu and D. WangObservation and Alteration of Surface States of Hematite Photoelectrodes. J. Phys. Chem. C, 118, 17054-17059.