Alan Rose

image of Alan Rose

Associate Project Scientist

Offices and Labs

126 Briggs Hall
(530)754-9892

Degrees

0 BS Biology University of Waterloo
0 MS Molecular Biology York University
0 PhD Molecular Biology Princeton University

Research Contribution

Understanding how gene expression works is important as basic science, and has numerous practical applications in biotechnology.

Research Interests

The effect of introns on gene expression.

Introns are often dismissed as junk DNA, but they can have huge effects on gene expression through mechanisms that are not yet understood. I am investigating this interesting phenomenon in plants using molecular genetics, and by testing bioinformatic insights generated by Dr. Ian Korf and his group.

Department and Center Affiliations

Molecular and Cellular Biology

CBS Grad Group Affiliations

Integrated Genetics and Genomics
Plant Biology
Biochemistry, Molecular, Cellular and Developmental Biology

Specialties / Focus

Plant Biology
  • Molecular Biology, Biochemistry, and Genomics
Integrated Genetics and Genomics
  • Model Plants
Biochemistry, Molecular, Cellular and Developmental Biology
  • Plant Biochemistry and Molecular Biology

Publications

1/19/2012 4:32:34 PM
  • Rose, A.B., S. Emami, K. Bradnam, and I Korf (2011). Evidence for a DNA-based mechanism of intron-mediated enhancement. Frontiers in Plant Science 2:98.
  • Parra, G., K. Bradnam, A. Rose, and I. Korf (2011). Comparative and functional analysis of intron-mediated enhancement signals reveals conserved features among plants. Nucleic Acids Research 39:5328-5337.
  • Rose, A.B., T. Elfersi, G. Parra, and I. Korf (2008) Promoter-Proximal Introns in Arabidopsis thaliana are Enriched in Dispersed Signals that Elevate Gene Expression. Plant Cell 20:543-551.
  • Rose, A.B. (2008). Intron-mediated regulation of gene expression. In Nuclear pre-mRNA Processing in Plants (A.S.N. Reddy and M. Golovkin, eds.) Springer-Verlag, New York. Current Topics in Microbiology and Immunology 326:277-290.
  • Rose, A.B. (2007) Book Review: Plant Gene Expression. Science STKE, pe26.
  • Belostotsky, D.A. and A.B. Rose (2005). Plant gene expression in the age of systems biology: Integrating transcriptional and post-transcriptional events. Trends in Plant Science 10:347-353.
  • Rose, A.B. (2004). The effect of intron location on intron-mediated enhancement of gene expression in Arabidopsis. Plant Journal 40:744-751.
  • Rose, A.B. (2002). Requirements for intron-mediated enhancement of gene expression in Arabidopsis. RNA. 8:1444-1453.
  • Shibagaki, N., A. Rose, J.P. McDermott, T. Fujiwara, H. Hayashi, T. Yoneyama, and J.P. Davies (2002). Selenate-resistant mutants of Arabidopsis thaliana identify Sultr1;2, a sulfate transporter required for efficient transport of sulfate into roots. Plant Journal 22:475-486.
  • Rose, A.B. and J.A. Beliakoff (2000). Intron-mediated enhancement of gene expression independent of unique intron sequences and splicing. Plant Physiology, 122:535-542.
  • Rose, A.B. and R.L. Last (1997). Introns act post-transcriptionally to increase expression of the Arabidopsis thaliana tryptophan pathway gene PAT1. Plant Journal 11:455-464.
  • Rose, A.B., J. Li, and R.L. Last (1997). An Allelic Series of Blue Fluorescent trp1 Mutants of Arabidopsis thaliana. Genetics 145:197-205.
  • Li, J., J. Zhao, A.B. Rose, R. Schmidt, and R.L. Last (1995). Arabidopsis phosphoribosylanthranilate isomerase: Molecular genetic analysis of triplicate tryptophan pathway genes. Plant Cell 7:447-461.
  • Rose, A.B., A.L. Casselman, and R.L. Last (1992). A phosphoribosylanthranilate transferase gene is defective in blue fluorescent Arabidopsis thaliana tryptophan mutants. Plant Physiology 100:582-592.

Labs

Alan Rose
25 Briggs Hall
  • Ian Haydon, Noah Kojima (Undergraduates).

Courses

PBI 298 Plant Molecular Biology Discussion
MCB 120L Biochemistry lab
BIS 102 Structure and Function of Macromolecules