Su Hao Lo

image of Su Hao Lo

Professor

Departments

Biochemistry and Molecular Medicine

Offices and Labs

Research I/UCDMC
(916)734-3656

Degrees

1997 Postdoctoral fellow U of Chicago, HHMI
1993 PhD Cell and Developmental Biology Harvard University
1986 BS National Taiwan University

Research Interests

Molecular and cell biolbogy

Our overall research interests are to understand the molecular mechanisms that underlie the structure and function of focal adhesions. Focal adhesions are integrin-mediated junctions that attach a variety of different cell types to their underlying substratum. They are signal transduction organelles and play a major role in diverse biological processes, including cell growth, attachment, migration, death, polarization, and differentiation. As such, focal adhesion dysfunction is known to have profound repercussions in embryogenesis, tissue development and repair, as well as in many pathological conditions including various forms of cancer.

Awards

Joan Oettinger Memorial Award (2008)
Shriners Hospitals Research Award (2003-2008)

Department and Center Affiliations

Biochemistry and Molecular Medicine; Orthopeadic surgery; Center for Tissue Regeneration and Repair; Cancer Center

ProfessionalSocieties

American Association for the Advancement of Science
American Society of Cell Biology
European Life Scientist Organization
Society for Basic Urologic Research

CBS Grad Group Affiliations

Biochemistry, Molecular, Cellular and Developmental Biology

Specialties / Focus

Biochemistry, Molecular, Cellular and Developmental Biology
  • Molecular Medicine

Graduate Groups not Housed in CBS

PTX, Comparative pathology

Labs

Irene Shih
  • PhD
Peng Sun
  • PhD
Shiao Ya Hong
  • PhD
Aifeng Wang
  • PhD
Gauri Khandekar
  • PhD

Publications

10/12/2016 9:15:41 PM
  • Hong, S. Y., Shih, Y.P., Sun, P., Hsieh, W. J., Lin, W. C. and Lo, S. H., Down-regulation of tensin2 enhances tumorigenicity and is associated with a variety of cancers. Oncotarget 2016 in press

  • Yang, K., Wu, W. M., Chen, Y. C., Lo, S. H., and Liao Y.C. ΔNp63α Transcriptionally Regulates the Expression of CTEN that Is Associated with Prostate Cell Adhesion. PLoS ONE 2016 11(1):e0147542.

  • Shih, Y. P., Sun, P., Wang, A., Lo, S. H. Tensin1 positively regulates RhoA activity through its interaction with DLC1. BBA Molecular Cell Research. 2015, 1853:3258-65

  •  Dina, C., Bouatia-Naji, N., Tucker, N., Delling, F.N., Toomer, K., Durst, R., Perrocheau, M., Fernandez-Friera, L., Solis, J., Tourneau, T., Chen, M.H., Probst, V., Bosse, Y., Pibarot, P., Zelenika, D., Lathrop, M, Hercberg, S., Rousse, R., Benjamin, E. J., Bonnet, F., Lo, S. H., Dolmatova, E., Simonet, F., Lecointe, S., Kyndt, F., Redon, R, Marec H., Froguel, P., Ellinor, P. T., Vasan, R. S., Bruneval, P., Norris, R. A., Milan, D. J., Slaugenhaupt, S. A., Levine, R. A., Schott, J., Hagege, A. A., Jeunemaitre, X.  Genetic association highlights biological pathways underlying mitral valve prolapse. Nat Genetics 2015 47(10):1206-11

  • Lo. S.H. C-terminal tensin-like (CTEN): a promising biomarker and target for cancer. J Biochem Cell Biol. 2014, 51:150-4

  • Hung, S.Y., Shih, Y.P., Chen, M., and Lo, S.H. Up-regulated cten by FGF2 contributes to FGF2-mediated cell migration. Mol Carcinog 2014, 53:787-792

  • Hong, S. Y., Shih, Y. P., Li, T., Carraway, K., Lo, S.H. CTEN Prolongs Signaling by EGFR through Reducing Its Ligand-Induced Degradation. Cancer Res. 2013 73(16):5266-76.
  • Chen, N.T., Kuwabara, Y., Conley, C., Liao, Y. C., Hong, S. Y., Chen, M., Shih, Y. P., Chen, H.W., Hsieh F., Lo, S. H. Phylogenetic analysis, expression patterns, and transcriptional regulation of human CTEN gene. Gene 2013 520(2):90-7.
  • Fujita, M., Ieguchi, K., Fong, A., Wilkerson, C., Chen, J.Q, Wu, M., Lo, S.H., Cheung, ATW., Wilson, M.D., Cardiff, R.D. , Borowsky, A.D, Yoko K. Takada, YK, and Takada, Y. An integrin-binding-defective mutant of insulin-like growth factor-1 (R36E/R37E IGF1) acts as a dominant-negative antagonist of IGF1R and suppresses tumorigenesis, while the mutant still binds to IGF1R. J Biol Chem. 2013 288(27):19593-603
  • Shih Y.P., Takada, Y., Lo, S.H. Silencing of DLC1 promotes PAI-1 expression and reduces normal cell migration. Mol Cancer Res. 2012, 10:34-39
  • Li, J.R., Shi, L., Deng, Z., Lo, S. H., Liu, G.Y. Nanostructures of Designed Geometry and Functionality Enable Regulation of Cellular Signaling Processes. Biochemistry 2012, 51:5876- 5893.
  • Shi L, Li, J.R., Shih, Y.P., Lo, S. H., Liu, G. Y., Nanogratings of Fibronectin Provide an Effective Biochemical Cue for Regulating Focal Adhesion and Cellular Structure. Nano Res 2012, 5(8): 565–575
  • Zimmer, C.C., Shi, L., Shih, Y.P., Li, J., Jin, LW, Lo, S.H. Liu, G.Y. F-Actin reassembly during focal adhesion impacts single cell mechanics and nanoscale membrane structure. Science China Chemistry, 2012, 55(9):1922-1930
  • Albasri, A., Al-Ghamdi, S., Fadhil, W., Aleskandarany, M., Liao, Y.C., Jackson, D., Lobo, D.N., Lo, S. H., Kumari, R., Durrant, L., Watson, S., Kindle, K.B., Ilyas, M. Cten signals through Integrin-linked Kinase (ILK) and may promote metastasis in colorectal cancer. Oncogene 2011, 30(26):2997-3002.
  • Wu. Z., Chang, P.C., Yang, Y.C., Chu, C. Y., Wang, L. Y., Chen, N. T., Desai, S. J., Lo, S. H., Evans, C. P., Lam, K. S., Kung, H. J. Autophagy blockade sensitizes prostate cancer cells towards Src family kinase inhibitors. Genes and Cancer 2010, 1:40-49
  • Lin, Y., Chen, N. T., Shih, Y. P., Liao, Y. C., Xue, L., and Lo, S. H, DLC2 modulates angiogenic responses in vascular endothelial cells by regulating cell attachment and migration. Oncogene 2010, 29:3010-301.
  • Shih, Y.P., Liao, Y.C., Lin, Y., Lo, S. H. DLC1 negatively regulates angiogenesis in a paracrine fashion. Cancer Res 2010 70:8270-8275.
  • Hsieh S. C., Chen, N. T., Lo, S. H. Conditional loss of PTEN leads to skeletal abnormalities and lipoma formation. Mol Carcinog. 2009, 48:545-552
  • Lulevich, V., Shih, I. P., Lo, S. H., and Liu, G. Y. Cell tracing dyes significantly change single cell mechanics. J Phys Chem 2009, 113:6511-6519
  • Liao, Y. C., Chen, N. T., Shih Y. P., Dong, Y., Lo, S. H. Up-regulation of C-terminal tensin-like molecule promotes the tumorigenicity of colon cancer cells through beta-catenin. Cancer Res 2009, 69:4563- 4566
  • Liao, Y. C., Shih, I. P., and Lo, S. H. Mutations in DLC-1’s focal adhesion targeting region attenuated its expression and function. Cancer Res 2008, 68:7718-7722
  • Liao, Y. C. and Lo, S. H. Deleted in Liver Cancer-1 (DLC-1): a tumor suppressor not just for liver. Int J Biochem Cell Biol. 2008, 40:834-847
  • Katz, M., Amit, I., Citri, A., Shay, T., Carvalho, S., Lavi, S., Milanezi, F., Lyass, L., Amariglio, N., Jacob-Hirsch, J., Ben-Chetrit, N., Tarcic, G., Lindzen, M., Avraham, R., Liao, Y. C., Trusk, P., Lyass, A., Rechavi, G., Spector, N. L., Lo, S. H., Schmtt, F., Bacus, S. S., Yarden, Y. A reciprocal tensin3-cten switch mediates EGF-driven mammary cell migration. Nat Cell Biol. 2007, 9:961-969.
  • Lo, S. H. Reverse interactomics: from peptides to proteins and to function. AC Chem. Biol. 2007, 2:93-95.
  • Liao, Y.C., Si, L., deVere White, R., and Lo, S. H. The phosphotyrosine-independent interaction of DLC-1 and the SH2 domain of cten regulates focal adhesion localization and growth suppression activity of DLC-1. J Cell Biol. 2007, 176:43-49
  • Lo, S. H. Focal adhesions: what's new inside. Dev. Biol. 2006, 294:280-91
  • Chen, N. T., and Lo, S. H. The N-terminal half of talin2 is sufficient for mouse development and survive. Biochem Biophys Res Commun. 2005, 337:670-676.
  • Lo, S. S., Lo, S. H., and Lo, S. H. Cleavage of cten by caspase 3 during apoptosis. Oncogene. 2005, 24:4311-4314.
  • Chiang, M. K., Liao, Y. C., Kuwabara, Y, and Lo, S. H. Targeted disruption of tensin3 in mice results in growth retardation and postnatal lethality. Dev. Biol. 2005, 279:368-377.
  • Lo, S. H. Molecules in focus: Tensin. Int J Biochem Cell Biol. 2004, 36:31-34.
  • Cui, Y., Liao, Y.C. and Lo, S. H. Epidermal growth factor modulates tyrosine phosphorylation of a novel tensin family member, tensin3. Mol Cancer Res. 2004, 2:225-232.
  • Chen, H. and Lo, S. H. Regulation of tensin-promoted cell migration by its focal adhesion-binding and Src Homology 2 domains. Biochem J. 2003, 370:1039-1045.
  • Lo, S. H. and Lo, T. B. CTEN, a C-terminal tensin-like protein with prostate restricted expression, is down regulated in prostate cancer. Cancer Res. 2002, 62:4217-4221.
  • Chen, H. Duncan, I. C. Bozorgchami, H. and Lo, S. H. Tensin1 and a previously undocumented family member, tensin2, positively regulate cell migration. Proc. Natl. Acad. Sci. USA 2002, 99:733-738.