Offices and Labs
Functional genomics of nervous system development.
My lab's main research interest is to understand molecular mechanisms of nervous system development in rodent model systems. We use DNA microarrays as a tool to identify genes that are developmentally regulated during mouse brain development. Candidate genes are characterized with molecular and cellular techniques and transgenic mice. In particular, my lab is interested in two areas: neural proliferation and synapse development. We have identified several candidate molecules that increase in gene expression during the period of neural proliferation or synapse formation and we are currently studying the role of two molecules (Mxd3 and SynDIG1) in these processes.
Department and Center Affiliations
CBS Grad Group Affiliations
Specialties / Focus
- Genomics, Proteomics and Metabolomics
- Molecular Genetics
- Cell Biology
- Developmental Biology
- Cancer Biology
Graduate Groups not Housed in CBS
Lyndsey Kirk, Graduate student (BMCDB)
Tin Ngo, Graduate student (BMCDB)
Abraham Corrales, Undergraduate student
Mayra Orozco-Llamas, Undergraduate student
Michelle Pham, Undergraduate student
Kris Plambeck, Graduate student (BMCDB)
Satake N, Duong C, Chen C, Barisone GA, Díaz E, Tuscano J, Rocke DM, Nolta J, and Nitin N. Targeted therapy with MXD3 siRNA, anti-CD22 antibody and nanoparticles for precursor B-cell acute lymphoblastic leukaemia. Br J Haematol. 2014 Sep 8. doi: 10.1111/bjh.13066. [Epub ahead of print]
Ngo T, Barisone GA, Lam KS, and Díaz E, MXD3 regulation of DAOY cell proliferation dictated by time course of activation, BMC Cell Biol. 2014, 15:30.
Barisone GA, Ngo T, Tran M, Cortes D, Shahi MH, Nguyen TV, Lanza-Perez D, Matayasuwan W, and Díaz E, Role of Mxd3 in proliferation of DAOY human medulloblastoma cells . PLoS ONE. 2012;7(7):e38508.
McMahon SA and Díaz E., Mechanisms of excitatory synapse maturation by trans-synaptic organizing complexes [invited review]. Curr Opin Neuro 2011, 21(2): 221-227
Kalashnikova E, Lorca RA, Kaur I, Barisone GA, Li BH, Ishimaru T, Trimmer JS, Mohapatra DP, and Díaz E. SynDIG1: an activity-regulated AMPA receptor interacting transmembrane protein that regulates excitatory synapse development, Neuron, 2010, 65: 80-93.
Díaz E (2010). Dynamic expression of SynDIG1 mRNA in cerebellar Purkinje neurons. Current Neurobiology, 1(1): 78-81.
Díaz E (2009), From microarrays to mechanisms of brain development and function [Invited review], Biochem Biophys Res Commun. 2009 Jul 24;385(2):129-31. Epub 2009 May 19.
Díaz E (2009), One decade later: What has gene expression profiling told us about neuronal cell types, brain function and disease? [Invited review]. Current Genomics, 10(5): 318-325.
Barisone GA, Yun JS, and DÃaz E (2008), From cellellar proliferation to tumorigenesis: novel insights into the role of Mad3 [invited Extra-View], Cell Cycle, [invited Extra-View], Cell Cycle, 7: 423-7. Epub 2007 Dec 6.
Yun JS, Rust JM, Ishimaru T, and Diaz E (2007), A novel role for the Mad family member Mad3 in cerebellar granule neuron precursor proliferation, Mol. Cell. Biol. 27: 8178-8189.
Diaz E, Ge Y, Yang YH, Loh KC, Serafini TA, Okazaki Y, Hayashizaki Y, Speed TP, Ngai J and Scheiffele P. (2002). Molecular analysis of gene expression in the developing pontocerebellar projection system. Neuron 36, 417-434.
Diaz E, Yang YH, Ferreira T, Loh KC, Okazaki Y, Hayashizaki Y, Tessier-Lavigne M, Speed TP and Ngai J (2003). Analysis of gene expression in the developing mouse retina, Proc. Natl. Acad. Sci. USA 100, 5491-5496.
Diaz E and Pfeffer SR (1998). TIP47: A cargo selection device for mannose 6-phosphate receptor trafficking. Cell 93, 433-443.