Offices and Labs
|1996||PhD||Physiology||NEOUCOM/Kent State University|
Central regulation of cardiopulmonary system
Blood pressure and heart rate are regulated by CNS on a moment-to-moment bases. Depending on the interaction between the genetic and environmental factors, the CNS regulatory output can result in either a normal or a pathological outcome. My research focuses on central regulation of cardiovascular function and how this regulation is altered in response to environmental factors such as exercise, stress, exposure to air pollution, hypertension, and obesity. I am particularly interested in how the neurons in the autonomic pathways change their intrinsic and/or synaptic properties as well as the neurotransmitter/neuromodulator and the receptors involved in the altered regulatory output. Studies are carried out in two major brainstem nuclei: the first central site that receives and integrates sensory information (Nucleus Tractus Solitarii) and the final output for cardiac parasympathetic motor nerves (Nucleus Ambiguus).
Department and Center Affiliations
CBS Grad Group Affiliations
Specialties / Focus
- Cardiorespiratory Physiology
- Cellular Physiology
- Systemic Physiology
Graduate Groups not Housed in CBS
Chen C.-Y., L. Matt, J. W. Hell and M. A. Rogawski. Perampanel Inhibition of AMPA Receptor Currents in Cultured Hippocampal Neurons. PLoS One 9(9):e108021, 2014.
Nystoriak, M. A., M. Nieves-Cintron, P. J. Nygren, S. A. Hinke, C. B. Nichols, C-Y. Chen, J. L. Puglisi, L. Izu, D. M. Bers, M. L. Dell’Acqua, J. Scott, L. F. Santana, and M. F. Navedo. AKAP150 Contributes to Enhanced Vascular Tone by Facilitating Large-Conductance Ca2+-Activated K+ Channel Remodeling in Hyperglycemia and Diabetes Mellitus. 114(4):607-615, 2014.
Sekizawa, S., B. A. Horwitz, J. M. Horowitz, and C-Y. Chen. Protection of signal processing at low temperature in baroreceptive neurons in the nucleus solitarius of Syrian hamsters, a hibernating species. Am. J. Physiol. Regul. Integr. Comp. Physiol. 305(10):R1153-62, 2013.
Horwitz, B. A., S. M. Chau, J. S. Hamilton, C. song, J. Gorgone, M. Saenz, J. M. Horowitz, and C-Y. Chen. Temporal relationships of blood pressure, heart rate, baroreflex function, and body temperature change over a hibernation bout in Syrian hamsters. Am. J. Physiol. Regul. Integr. Comp. Physiol. 305(7):R759-68, 2013.
Sekizawa, S., J. M. Horowitz, B. A. Horwitz, and C-Y. Chen. Realignment of signal processing within a sensory brainstem nucleus as brain temperature declines in the Syrian hamster, a hibernating species. Journal of Comparative Physiology A 198:267-282, 2012.
Chen C-Y., A. C. Bonham, C. Dean, F. A. Hopp, C. J. Hillard, and J. L. Seagard. Retrograde release of endocannabinoid inhibits presynaptic GABA release in baroreceptive second-order neurons in NTS Autonom. Neurosci. 158:44-50, 2010.
Chen C-Y. and A.C. Bonham. Postexercise hypotension: central mechanisms. Exercise and Sport Sciences Reviews 38:122-127, 2010.
Howell, L.P., C-Y. Chen, J. Joad, R. Green, E. Callahan, A.C. Bonham. Addressing the Issues and Challenges of Non-Tenure Track Research Faculty at the UCDavis School of Medicine. Acad. Med. 85(6): 1041-1047, 2010.
Zhong, C-Y., Y-M. Zhou, K.R. Smith, I.M. Kennedy, C-Y. Chen, A.E. Aust, K.E. Pinkerton. Oxidative injury in the lungs of neonatal rats following short-term exposure to ultrafine iron and soot particles. J. Toxicol. Environ. Health. 73:837-847, 2010.
Pham, H., A. C. Bonham, K. E. Pinkerton, C-Y. Chen. Central neuroplasticity and decreased heart rate variability following particulate matter exposure in mice. Environmental Health Perspective. 117(9): 1448 – 53., 2009
Chen, C-Y., A.G. Bechtold, J.M. Tabor, and A.C. Bonham. Post-exercise hypotension is associated with neurokinin 1 receptor internalization. J. Neurosciences. 29:2754-2761., 2009
C-Y. Chen, J. P. Joad, J. Bric, and A. C. Bonham. Central mechanisms I: plasticity of central pathways. In: Pharmacology and Therapeutics of Cough. Eds: K. F. Chung and J. Widdicombe. Springer-Verlag Berlin Heidelberg, 2009