Chao-Yin Chen

image of Chao-Yin Chen

Professor

Departments

Pharmacology - Medicine

Offices and Labs

2217 Tupper Hall
754-6458

Degrees

1996 PhD Physiology NEOUCOM/Kent State University

Research Interests

Central regulation of cardiopulmonary system

Blood pressure and heart rate are regulated by CNS on a moment-to-moment bases. Depending on the interaction between the genetic and environmental factors, the CNS regulatory output can result in either a normal or a pathological outcome. My research focuses on central regulation of cardiovascular function and how this regulation is altered in response to environmental factors such as exercise, stress, exposure to air pollution, hypertension, and obesity. I am particularly interested in how the neurons in the autonomic pathways change their intrinsic and/or synaptic properties as well as the neurotransmitter/neuromodulator and the receptors involved in the altered regulatory output. Studies are carried out in two major brainstem nuclei: the first central site that receives and integrates sensory information (Nucleus Tractus Solitarii) and the final output for cardiac parasympathetic motor nerves (Nucleus Ambiguus).

Awards

2003 American Physiological Society NCAR Young Investigator Award
2002-3 Postdoctoral Fellowship Award, AHA Western States Affiliate
1996 Excellence for Doctoral dissertation, Kent State University
1996 David B. Smith Fellowship. Kent State University
1995 Excellence in research. Kent State University

Department and Center Affiliations

Department of Pharmacology

ProfessionalSocieties

American Physiological Society
The Society for Neuroscience

CBS Grad Group Affiliations

Molecular, Cellular, and Integrative Physiology

Specialties / Focus

Molecular, Cellular, and Integrative Physiology
  • Cardiorespiratory Physiology
  • Neurophysiology
  • Cellular Physiology
  • Systemic Physiology

Graduate Groups not Housed in CBS

Pharmacology and Toxicology (PTX)

Labs

  • Soundarya Kumaravelu
  • Emma Karey
  • Shiyue (June) Pan
  • Junqing Sun
  • Judy Pan
  • Andrew Bellaart
  • Yumeng Fu
  • Rahyul Jog
  • Cynthia Katasi
  • Mashal Shah

Courses

MCP 290 Putting physiology to work: Surgical solution to hypertension (Fall)
MCP / PTX 215 Electrophysiology Techniques and Applications (Spring)
MCP 210B Advanced Physiology - Autonomic and cardiovascular physiology (Winter)

Publications

10/21/2017 9:59:00 AM
  • Pinkerton, K.E., M. J. Kleeman, A. S. Wexler, and C.-Y. Chen.  Particle dose related to effects of concentrated ambient particles on cardiac autonomic function and arrhythmia burdens at rest and during stress in mice.  In: Advances in inhaled aerosol dosimetry research conference proceedings, 2017.

  • Chen, C.-Y., J. Di Lucente, YC Lin, CC Lien, M.A. Rogawski, I. Maezawa, L.W. Jin.  Defective GABAergic neurotransmission in the nucleus tractus solitarius in Mecp2-null mice, a model of Rett syndrome.  Neurobiology of Disease (in press), 2017

  • Ca2+/calmodulin binding to PSD-95 mediates homeostatic synaptic scaling down.  EMBO J. (in press), 2017.

  • Chen, C-Y.  Patch clamp technique and applications.  In: Modern tools of biophysics.  Springer Nature, 2017

  • Patriarchi T, Qian H, Di Biase V, Malik ZA, Chowdhury D, Price JL, Hammes EA, Buonarati OR, Westenbroek RE, Catterall WA, Hofmann F, Xiang YK, Murphy GG, Chen CY, Navedo MF, Hell JW.  Phosphorylation of Cav1.2 on S1928 uncouples the L-type Ca2+ channel from the β2 adrenergic receptor.  EMBO J. 35(12):1330-45, 2016

  • Nystoriak, M. A., M. Nieves-Cintron, P. J. Nygren, S. A. Hinke, C. B. Nichols, C-Y. Chen, J. L. Puglisi, L. Izu, D. M. Bers, M. L. Dell’Acqua, J. Scott, L. F. Santana, and M. F. Navedo.  AKAP150 Contributes to Enhanced Vascular Tone by Facilitating Large-Conductance Ca2+-Activated K+ Channel Remodeling in Hyperglycemia and Diabetes Mellitus.  114(4):607-615, 2014.

  • Chen, C.-Y., L. Matt, J. W. Hell and M. A. Rogawski.  Perampanel Inhibition of AMPA Receptor Currents in Cultured Hippocampal Neurons.  PLoS One 9(9):e108021, 2014.

  • Chen C.-Y., L. Matt, J. W. Hell and M. A. Rogawski.  Perampanel Inhibition of AMPA Receptor Currents in Cultured Hippocampal Neurons.  PLoS One 9(9):e108021, 2014.

  • Nystoriak, M. A., M. Nieves-Cintron, P. J. Nygren, S. A. Hinke, C. B. Nichols, C-Y. Chen, J. L. Puglisi, L. Izu, D. M. Bers, M. L. Dell’Acqua, J. Scott, L. F. Santana, and M. F. Navedo.  AKAP150 Contributes to Enhanced Vascular Tone by Facilitating Large-Conductance Ca2+-Activated K+ Channel Remodeling in Hyperglycemia and Diabetes Mellitus.  114(4):607-615, 2014.

  • Horwitz, B. A., S. M. Chau, J. S. Hamilton, C. song, J. Gorgone, M. Saenz, J. M. Horowitz, and C-Y. Chen.  Temporal relationships of blood pressure, heart rate, baroreflex function, and body temperature change over a hibernation bout in Syrian hamsters.  Am. J. Physiol. Regul. Integr. Comp. Physiol. 305(7):R759-68, 2013.

  • Sekizawa, S., B. A. Horwitz, J. M. Horowitz, and C-Y. Chen.  Protection of signal processing at low temperature in baroreceptive neurons in the nucleus solitarius of Syrian hamsters, a hibernating species.  Am. J. Physiol. Regul. Integr. Comp. Physiol.  305(10):R1153-62, 2013

  • Sekizawa, S., B. A. Horwitz, J. M. Horowitz, and C-Y. Chen.  Protection of signal processing at low temperature in baroreceptive neurons in the nucleus solitarius of Syrian hamsters, a hibernating species.  Am. J. Physiol. Regul. Integr. Comp. Physiol.  305(10):R1153-62, 2013.

  • Horwitz, B. A., S. M. Chau, J. S. Hamilton, C. song, J. Gorgone, M. Saenz, J. M. Horowitz, and C-Y. Chen.  Temporal relationships of blood pressure, heart rate, baroreflex function, and body temperature change over a hibernation bout in Syrian hamsters.  Am. J. Physiol. Regul. Integr. Comp. Physiol. 305(7):R759-68, 2013.

  • Sekizawa, S., J. M. Horowitz, B. A. Horwitz, and C-Y. Chen. Realignment of signal processing within a sensory brainstem nucleus as brain temperature declines in the Syrian hamster, a hibernating species. Journal of Comparative Physiology A 198:267-282, 2012.