Reen Wu

image of Reen Wu



Internal Medicine - Medicine

Offices and Labs

GBSF, Room 6523

Profile Introduction

Gene expression and regulation in airway epithelium


1972 PhD Biochemistry University of Arkansas Medical Center

Research Interests

Gene expression and regulation in airway epithelium


1972-74 American Cancer Society Postdoctoral Fellowship
1974-76 NIH National Research Service Award
1993 Joan Oettinger Memorial Award, School of Medicine
1996 Faculty Research Award, School of Medicine
2000 NIH merit award, R37 HL35635

Department and Center Affiliations

Department of Internal Medicine/Pulmonary & Critical Care Medicine
VM Anatomy, Physiology and Cell Biology
Center for Comparative Respiratory Biology and Medicine


American Thoracic Society
American Society for Biochemistry and Molecular Biology
Oxygen Society
American Association for the Advancement of Science
The American Association of Immunologist

CBS Grad Group Affiliations

Integrated Genetics and Genomics

Specialties / Focus

Integrated Genetics and Genomics
  • Human Genetics and Genomics
Biochemistry, Molecular, Cellular and Developmental Biology
  • Cellular Responses to Toxins and Stress
  • Molecular Medicine
Molecular, Cellular, and Integrative Physiology
  • Cellular Physiology
  • Cardiorespiratory Physiology

Graduate Groups not Housed in CBS

Comparative Pathology Graduate group, Pharmacology and Toxicology Graduate Group


Center for Comparative Respiratory Biology and Medicine, GBSF
  • Dr. Mary Chang, Dr. Richart Harper, Dr. Philip Thai, Dr. Karen Oslund, Ken Chmiel, Fei Huang, Shinchiro Wachi, Laura Shih, Christy Kim, Li-Yin Hung, Keny Lin, Daphne Wu, Artem Loukoianov, Pimtip Sanvarinda

Teaching Interests

I am interested to teach students the laboratory skills and how to conduct research. I am also interested to teach advance courses related to cell/molecular basis of the diseases, and also my


PMI 285 Cellular basis of disease (Winter)
APC 291 Center for Comparative Respiratory Biology and Medicine seminar series (Fall,Winter,Spring)


5/21/2010 9:26:34 AM
  • Chen, Y., Zhao, Y.H., Kalaslavadi, T.J., Hamati, E., Nehrke, K., Le, A.D., Ann, D.K., and Wu, R. Genome-wide search of novel gel-forming mucin genes and identification of MUC19/Muc19 as a new glandular tissue-specific mucin gene. Am. J. Respir. Cell Mol. Biol., 30: 155-165, 2004.
  • Chen, Y, Thai, P., Zhao, Y.H., Ho, Y.S., DeSouza, M.M., and Wu, R. Stimulation of airway mucin gene expression by IL-17 through IL-6 paracrine/autocrine loop. J. Biol. Chem. 278: 17036-17043, 2003.
  • Kao, C.Y, Chen, Y., Zhao, Y.H., and Wu, R. ORFeome based search of airway epithelial cell-specific novel human b-defensin genes. Am. J. Respir. Cell Mol. Biol. 29: 71-80, 2003.
  • Di, Y.P., Zhao, Y.H., Harper, R., and Wu, R. Molecular cloning, and characterization of a human novel gene that is retinoic acid-inducible and encodes a secretory protein specific in upper respiratory tracts, SPURT. J. Biol. Chem. 278:1165-1173, 2003.
  • Kao, C.Y, Chen, Y, Thai, P., Wachi, S., Huang, F., Kim, C., Harper, R.W., and Wu, R. Interleukin-17 Markedly Up-Regulates b-Defensin 2 Expression in Human Airway Epithelium via JAK and NF-kB Signaling Pathways. J. Immunol. 173: 3482-3491, 2004.
  • Harper, R W, Xu C, Eiserich JP, Kao CY, Thai P, Setiadi H, and Wu, R. Differential regulation of dual NADPH oxidase/peroxidase, Duox 1 and Duox 2, by Th1 and Th2 cytokines in respiratory tract epithelium. FEBS Letter, 579: 4911-4917, 2005.
  • Kao CY, Huang F., Chen Y., Thai P, Wachi, S, Kim C, Tam L and Wu R. Up-regulation of CC chemokine ligand 20 expression in human airway epithelium by IL-17 through a JAK-independent but MEK/NF-kappaB-dependent signaling pathway. J. Immunol. 175: 6676-6685, 2005.
  • Thai, P., Chen Y, Dolganov G, and Wu, R. Differential regulation of MUC5AC/Muc5ac and hCLCA-1/mGob-5 expression in airway epithelium. American J. Respir. Cell Mol. Biol. 33(6):523-30, 2005.
  • Wachi S., Yoneda K, and Wu R. Interactome-transcriptome analysis reveals the high centrality of genes differentially expressed in lung cancer tissues. Bioinformatics, 21(23):4205-8, 2005.
  • Chen,Y., Hamati, E., Lee, W.M., Wachi, S., Schnurr, D., Shigeo, Y., Dolganov, G., Boushey, H., and Wu, R. Rhinovirus induces airway epithelial gene expression through double-stranded RNA and IFN-dependent pathways. Am. J. Respir. Cell Mol. Biol. 34: 192-203, 2006.
  • Wu, D.Y-C, Wu, R., Reddy, S.P., Lee, Y.C., and Chang, M. M-J. Distinctive EGFR/ERK-Independent and Dependent Signaling Pathways in the Induction of Airway MUC5B and MUC5AC Expression by PMA. J. Am. Pathol. 170(1) 20-32, 2007.
  • Wu DPC, Wu R, Chen Y, Tarasova N, and Chang MMJ. PMA stimulates MUC5B gene expression through an SP1-based mechanism in airway epithelial cells. Am. J. Respir. Cell Mol. Biol. 37: 589-597, 2007.
  • Thai P, Loukoianov A, Wachi S, and Wu R. Regulation of airway mucin gene expression. Annu. Rev. Physiol. 70: 13.1-13.25, 2008.