Nobuko Hagiwara

image of Nobuko Hagiwara

Associate Professor


Cardiology (Internal Med)

Offices and Labs

Tupper Hall 1442


1995 PhD Molecular Biology University of Tokyo
1987 MS Genetics Ochanomizu Women's University
1984 BS Biology Ochanomizu Women's University

Research Interests

Development and disease of skeletal muscle and the heart

Department and Center Affiliations

Internal Medicine, Division of Cardiovascular Medicine


American Heart Association, Society for Neuroscience, International Mammalian Genome Society, Society for Developmental Biology

CBS Grad Group Affiliations

Integrated Genetics and Genomics
Biochemistry, Molecular, Cellular and Developmental Biology

Specialties / Focus

Integrated Genetics and Genomics
  • Human Genetics and Genomics


Tupper 1445

Teaching Interests

Mammalian genetics and development
Medical Genetics


Genetics MDS 406 ENRG (Block 2)
GGG 211 Concepts in Human Genetics and Genomics
GGG 294 Seminar in Human Genetics


1/24/2012 12:49:54 PM
  • Hagiwara, N., Yeh M, and Liu A. (2007) Sox6 is required for normal fiber type differentiation of fetal skeletal muscle in mice. Dev. Dynamics 236: 2062-2076
  • Yi, Z., Cohen-Barak, O., Hagiwara, N., Kingsley, P.D., Fuchs, D.A., Erickson, D.T., Epner, E.M., Palis, J., and Brilliant, M.H. (2006) Sox6 directly silences epsilon globin expression in definitive erythropoiesis. PLoS Genetics 2: e14
  • Hagiwara, N., Ma, B., and Ly, A. (2005) Slow and fast fiber isoform gene expression is systematically altered in skeletal muscle of the Sox6 mutant, p100H. Dev. Dynamics 234:301-311
  • Hagiwara, N., Katarova, Z., Siracusa, L.D., and Brilliant, M.H. (2003) Non-neuronal expression of the GABAA beta3 subunit gene is required for normal palate development in mice. Dev. Biol. 254:93-101.
  • Cohen-Barak, O., Yi, Z., Hagiwara, N., Monzen, K., Komuro, I., and Brilliant, M. H. (2003) Sox6 regulation of cardiac myocytes development. Nuc. Acids Res. 31: 5941-5948.
  • Cohen-Barak, O, N Hagiwara, MF Arlt, JP Horton, and MH Brilliant. (2001) Cloning, characterization and chromosome mapping of the human SOX6 gene. Gene. 265:157-164
  • Hagiwara, N., SE Klewer, RA Samson, DT Erickson, MF Lyon and MH Brilliant. (2000) SOX6 is a candidate gene for p100H myopathy, heart block and sudden neonatal death. Proc. Natl. Acad. Sci. USA. 97:4180-4185
  • Hagiwara, N. (2011) Sox6, jack of all trades: A versatile regulatory protein in vertebrate development. Dev. Dyn. 240: 1311-1321
  • An, C., Dong, Y., and Hagiwara, N. (2011) Genome-wide mapping of Sox6 binding sites in skeletal muscle reveals both direct and indirect regulation of muscle terminal differentiation by Sox6. BMC Dev. Biol. 11(1):59.