Kermit Carraway

image of Kermit Carraway

Professor

Departments

Co-Director, Molecular Oncology Program, UC Davis Comprehensive Cancer Center
Co-Founder, Breast Cancer Research Program, UC Davis Comprehensive Cancer Center
Biochemistry and Molecular Medicine

Offices and Labs

Research Bldg. III, Room 1100B, UCDMC
(916) 734-3114

Degrees

1996 Postdoc Signal Transduction Harvard Medical School
1992 PhD Biochemistry, Cell and Molecular Biology Cornell University
1985 BS Biochemistry University of Illinois

Research Interests

Cancer biology and therapeutics

Research in the lab centers on elucidating the cellular and molecular mechanisms underlying tumor formation and progression, and developing strategies and agents that could interfere with these processes. We are specifically interested in post-transcriptional regulatory pathways, such as cellular trafficking and degradation of growth factor receptors and disruption of cell polarity pathways, that contribute to cancer malignancy. We use biochemical and cell biological methods to elucidate these pathways in cultured tumor cells, genetically engineered mice to characterize dysregulated tumorigenic pathways in vivo, and drug development and characterization methods to inhibit these pathways.

Developental biology

We use genetically engineered mice and transplant methods to explore the roles of specific genes and signaling pathways in the development of the mammary gland and other tissues, as well as in embryonic development.

Department and Center Affiliations

UC Davis Comprehensive Cancer Center
Med Biochemistry and Molecular Medicine

CBS Grad Group Affiliations

Biochemistry, Molecular, Cellular and Developmental Biology

Specialties / Focus

Biochemistry, Molecular, Cellular and Developmental Biology
  • Molecular Medicine
  • Cell Biology
  • Biochemistry
  • Developmental Biology
  • Cancer Biology
  • Cellular Responses to Toxins and Stress
  • Organelle and Membrane Biology
  • Signal Transduction

Graduate Groups not Housed in CBS

Pharmacology and Toxicology
Comparative Pathology

Teaching Interests

Cancer biology
Biochemistry, cell biology and metabolism
Signal transduction

Courses

PTX 201 Principles of Pharmacology and Toxicology I (Fall)
PTX 202 PTX 202 Principles of Pharmacology and Toxicology II (Winter)
PTX 203 Principles of Pharmacology and Toxicology III (Spring)
MCB 257 Cell proliferation and cancer genes (Fall)
BCM 410A Med Biochemistry (Fall)

Publications

8/31/2015 11:30:33 AM
  • Carraway, K.L., III, Weber, J.L., Unger, M.J., Ledesma, J., Yu, N., Gassmann, M., and Lai, C. 1997. Neuregulin-2, a new ligand of ErbB3/ErbB4-receptor tyrosine kinases. Nature 387, 512-516.
  • Carraway, K.L., III, and Sweeney, C. 2001. Localization and modulation of ErbB receptor tyrosine kinases. Curr. Opin. Cell Biol. 13, 125-130.
  • Diamonti, A.J., Guy, P.M., Ivanof, C., Wong, K., Sweeney, C. and Carraway, K.L., III. 2002. An RBCC protein implicated in maintenance of neuregulin receptor levels. Proc. Natl. Acad. Sci. USA 99, 2866- 2871.
  • Ghiglione, C., Amundadottir, L., Andresdottir, M., Bilder, D., Diamonti, J. A., Noselli, S., Perrimon, N., and Carraway, K.L., III. 2003. Mechanism of inhibition of the Drosophila and mammalian EGF receptors by the transmembrane protein Kekkon 1. Development 130, 4483-4493.
  • Wu, X., Yen, L., Irwin, L., Sweeney, C., and Carraway, K. L., III. 2004. Stabilization of the E3 ubiquitin ligase Nrdp1 by the deubiquitinating enzyme USP8. Mol. Cell. Biol. 24, 7748-7757.
  • Funes, M., Miller J.K., Lai, C., Carraway, K.L. III, and Sweeney C. 2006. The Mucin Muc4 potentiates Neuregulin signaling by increasing the cell surface populations of ErbB2 and ErbB3. J. Biol. Chem. 281, 19310-19319.
  • Sweeney, C., Miller, J.K., Shattuck, D.L., and Carraway K.L. III. 2006. ErbB receptor negative regulatory mechanisms: implications in cancer. J. Mammary Gland Biol. Neoplasia 11, 89-99.
  • Carraway, K.L., III, and Sweeney, C. 2006. Co-opted integrin signaling in ErbB2 induced mammary tumor progression. Cancer Cell 10, 93-5.
  • Yen, L., Cao, Z., Wu, X., Ingalla, E., Baron, C., Young, L., Gregg, J.P., Cardiff, R.D., Borowsky, A.D., Sweeney, C. and Carraway, K.L., III. 2006. Loss of Nrdp1 enhances ErbB2-ErbB3 dependent breast tumor cell growth. Cancer Res. 66, 11279-86.
  • Cao, Z., Wu, X., Yen, L., Sweeney, C. and Carraway, K.L., III. 2007. Neuregulin induced ErbB3 down-regulation is mediated by a protein stability cascade involving the E3 ubiquitin ligase Nrdp1. Mol. Cell. Biol. 27, 2180-2188.
  • Fry, W.H., Kotelawala, L., Sweeney, C., Carraway. K.L., III. 2009. Mechanisms of ErbB receptor negative regulation and relevance in cancer. Exp. Cell Res. 68, 8286-8294.
  • Workman, H.C., Sweeney, C., and Carraway, K.L., III. 2009. The membrane mucin Muc4 inhibits apoptosis induced by multiple insults via ErbB2-dependent and ErbB2-independent mechanisms. Cancer Res. 69, 2845-2852.
  • Ingalla, E.Q., Miller, J.K., Wald, J.H., Workman, H.C., Kaur, R.P., Yen, L., Fry, W.H.D., Borowsky, A.D., Young, L.J.T., Sweeney, C., and Carraway, K.L., III. 2010. Post-transcriptional regulatory mechanisms contribute to the suppression of the ErbB3 negative regulator protein Nrdp1 in mammary tumors. J. Biol. Chem. 285, 28691-28697.
  • Carraway, K.L., III. 2010. E3 ubiquitin ligases in ErbB receptor quantity control. Sem. Cell Dev. Biol. 21, 936-943.
  • Fry, W.H., Simion, C., Sweeney, C., and Carraway, K.L. III. 2011. Quantity control of the ErbB3 receptor tyrosine kinase at the endoplasmic reticulum. Mol. Cell. Biol. 31, 3009-3018.
  • Leon, L.J., Pasupuleti, N., Gorin, F., and Carraway, K.L., III. 2013. A cell-permeant amiloride derivative induces caspase-independent, AIF-mediated programmed necrotic death of breast cancer cells. PLoS One 8, e63038.

  • Hatakeyama, J., Wald, J.H., Printsev, I., Ho, H.Y., and Carraway, K.L., III. 2014. Vangl1 and Vangl2: planar cell polarity components with a developing role in cancer. Endocr Relat Cancer 21, R345-356.

  • Printsev, I., Yen, L., Sweeney, C., and Carraway, K.L., III. 2014. Oligomerization of the Nrdp1 E3 ubiquitin ligase is necessary for efficient autoubiquitination but not ErbB3 ubiquitination. J. Biol. Chem. 289, 8570-85788.