Martha O'Donnell

image of Martha O'Donnell

Professor of Physiology and Membrane

Departments

Physiology and Membrane Biology

Offices and Labs

4155 Tupper Hall
752-7626

Profile Introduction

Ion transport, signal transduction, ischemic stroke, cerebral edema, brain microvascular endothelial cells, astrocytes, diabetes

Degrees

B.S. University of California, Davis
Ph.D. University of California, Davis
Postdoctoral fellowship University of Chicago

Research Interests

Ischemic stroke

Stroke, cerebral edema, diabetes, estrogen, brain microvascular endothelial cells, astrocytes, ion transport, aquaporin

Department and Center Affiliations

Department of Physiology and Membrane Biology

ProfessionalSocieties

American Physiological Society
American Society for Cell Biology
Microcirculatory Society
North American Vascular Biology Organization
American Heart Association Stroke Council
Society for Neuroscience
International Society for Cerebral Blood Flow and Metabolism

CBS Grad Group Affiliations

Molecular, Cellular, and Integrative Physiology
Biochemistry, Molecular, Cellular and Developmental Biology

Specialties / Focus

Biochemistry, Molecular, Cellular and Developmental Biology
  • Cellular Responses to Toxins and Stress
  • Molecular Physiology
  • Signal Transduction
Molecular, Cellular, and Integrative Physiology
  • Cellular Physiology
  • Molecular Physiology
  • Metabolic Physiology
  • Neurophysiology

Labs

O'Donnell laboratory, 4152/4149 Tupper Hall website
  • Olga Chechneva, PhD, Assistant Project Scientist; Jay Chen, DVM, PhD, Assistant Professor; Nicholas Klug, BS, PhD student; Logan Little, BS, Jr. Specialist; Michelle Riley, PhD, Postdoctoral Fellow; Steve Anderson, PhD, Research Physiologist

Teaching Interests

Cellular physiology, Cell signalling, Ion transport, Cerebrovascular physiology, Epithelial cell physiology, G.I. physiology

Courses

HPH 400 Human Physiology (Fall)
MCP 210A Advanced Physiology (Physiology Core Course) (Fall)

Publications

10/20/2015 12:39:36 PM
  • O'Donnell, M.E., A. Martinez and D. Sun (1995) Cerebral microvascular endothelial cell Na-K-Cl cotransport: regulation by astrocyte-conditioned medium. American Journal of Physiology 268: C747-C754.
  • O'Donnell, M.E., J.D. Brandt, and F.E. Curry (1995) Na-K-Cl cotransport regulates intracellular volume and monolayer permeability of trabecular meshwork cells. American Journal of Physiology, 268: C1067-C1074.
  • Sun, D., C. Lytle and M.E. O'Donnell (1995) Astroglial cell-induced expression of Na-K-Cl cotransporter in brain microvascular endothelial cells. American Journal of Physiology, 269: C1506-C1512.
  • O'Donnell, M.E., A. Martinez and D. Sun (1995) Endothelial Na-K-Cl cotransport regulation by tonicity and hormones: phosphorylation of cotransport protein. American Journal of Physiology, 269: C1513-C1523.
  • Sun, D. and M.E. O'Donnell (1996) Astroglial-mediated phosphorylation of the Na-K-Cl cotransporter in brain microvessel endothelial cells. American Journal of Physiology, 271: C620-C627.
  • Sun, D., C. Lytle and M.E. O'Donnell (1997) IL-6 secreted by astroglial cells regulates Na-K-Cl cotransport in brain microvessel endothelial cells. American Journal of Physiology, 272: C1829-C1835.
  • Putney, L.K., J.D. Brandt, and M.E. O'Donnell (1997) Effects of dexamethasone on sodium-potassium-chloride cotransport in trabecular meshwork cells. Investigative Ophthalmology and Visual Science 38: 1229-1240.
  • Yerby, T.R., C.R.T. Vibat, D. Sun, J.A. Payne and M.E. O'Donnell (1997) Molecular characterization of the Na-K-Cl cotransporter of bovine aortic endothelial cells. American Journal of Physiology 273: C188-C197.
  • Kajimura, M., M.E. O'Donnell and F.E. Curry (1997) Effect of cell shrinkage on permeability of cultured bovine aortic endothelia and frog mesenteric capillaries. Journal of Physiology 503: 413-425.
  • Cai, S., L. Pestic, M.E. O'Donnell, N. Wang, D. Ingber, E. Elson and P. de Lanerolle (1998) Regulation of cytoskeletal mechanics and cell growth by myosin light chain kinase. American Journal of Physiology 275: C1349-C1356.
  • Putney, L.K., J.D. Brandt and M.E. O'Donnell (1998) Na-K-Cl cotransport in normal and glaucomatous human trabecular meshwork cells. Investigative Ophthalmology and Visual Science 40: 425-434.
  • Putney, L.K., C.R.T. Vibat and M.E. O'Donnell (1999) Intracellular Cl regulates Na-K-Cl cotransport activity in human trabecular meshwork cells, American Journal of Physiology 277: C373-C383
  • Al-Aswad, L. A., J. Gong, D. Lee, M.E. O'Donnell, J.D. Brandt, W. J. Ryan and K.A. Erickson (1999) Effects of Na-K-2Cl cotransport regulators on outflow facility in calf and human eyes in vitro. Investigative Ophthalmology and Visual Science 40 (8): 1695-1701.
  • Brandt, J.D. and M.E. O'Donnell (1999) How does the trabecular meshwork regulate outflow? Clues from the microvascular endothelium, Journal of Glaucoma 8 (5):328-339.
  • Suvatne, J., A. Barakat and O'Donnell, M.E (2001) Flow-induced expression of endothelial Na-K-Cl cotransport: dependence on K+ and Cl- channels, American Journal of Physiology-Cell Physiology 280: c216-227.
  • Stamer, W. D., K.C. Peppel, M.E. O'Donnell, B.C. Roberts, F. Wu and D.L. Epstein (2001) Expression of aquaporin-1 in human trabecular meshwork cells: role in resting cell volume, Investigative Ophthalmology and Visual Science 42: 1803-1811.
  • Vibat, C.R.T, M.J. Holland, J.J. Kang, L.K. Putney and M.E. O'Donnell (2001) Quantitation of Na+-K+-2Cl- cotransport splice variants in human tissues using kinetic PCR, Analytical Biochemistry 298: 218-230.
  • O'Donnell, M.E., J. Suvatne, P.A. Pappone and J.D. Brandt (2001) Activation of ion conductances in human trabecular meshwork cells by swelling and by niflumic acid. Investigative Ophthalmology and Visual Science 42: S138.
  • O'Donnell, M.E., L. Tran, T. Lam, X.B. Liu and S.E. Anderson (2004). Bumetanide inhibition of the blood-brain barrier Na-K-Cl cotransporter reduces edema formation in the rat middle cerebral artery occlusion model of stroke. Journal of Cerebral Blood Flow and Metabolism, 24: 1046-1056.
  • T. I. Lam, S.E. Anderson, N. Glaser and M. E. O'Donnell (2005). Bumetanide reduces cerebral edema formation in rats with diabetic ketoacidosis. Diabetes 54: 510-516.
  • O'Donnell, M.E., V. Duong, S. Suvatne, S. Foroutan, and D. M. Johnson (2005). Arginine vasopressin stimulation of cerebral microvascular endothelial cell Na-K-Cl cotransport activity is V1 receptor- and [Ca]-dependent. American Journal of Physiology, 289: C283-C292.
  • Foroutan, S., J. Brillault, B. Forbush, and M.E. O'Donnell (2005). Moderate to severe ischemic conditions increase activity and phosphorylation of the cerebral microvascular endothelial cell Na-K-Cl cotransporter. American Journal of Physiology: Cell Physiology 289: C1492-C1501.
  • M.E. O'Donnell, T.I. Lam, L. Tran and S.E. Anderson (2005). The role of the blood-brain barrier Na-K-Cl cotransport in stroke. In: P.Lauf and N. Adragna, eds, Cell Volume and Signaling, Advances in Experimental Biology and Medicine, Proceedings of the 2003 International Symposium on Cell Volume Regulation. Vol. 559, pp 67-75, Springer Publishers.
  • O'Donnell, M.E., T. I. Lam, L.Q. Tran, S. Foroutan and S.E. Anderson (2006). Estradiol reduces activity of the blood-brain barrier Na-K-Cl cotransporter and decreases edema formation in permanent middle cerebral artery occlusion. Journal of Cerebral Blood Flow and Metabolism 26: 1234-1249.
  • Pedersen, S.F., M.E. O'Donnell, S.E. Anderson, and P.M. Cala (2006). Physiology and pathophysiology of Na+/H+ exchange and Na+/K+/2Cl- cotransporter in the heart, brain, and blood. American Journal of Physiology: Regulatory, Integrative and Comparative Physiology 291; R1-R25.
  • Brillault, J., T.I. Lam, J.M. Rutkowsky, S. Foroutan and M.E. O'Donnell (2007). Hypoxia effects on cell volume and ion uptake of cerebral microvascular endothelial cells. American Journal of Physiology: Cell Physiology doi: 10.1152/ajpcell.00148.2007.
  • Chang, E., M.E. O'Donnell and A.I. Barakat. Shear stress and 17?-estradiol modulate cerebral microvascular endothelial Na-K-Cl cotransporter and Na/H exchanger protein levels (2007). American Journal of Physiology: Cell Physiology doi: 10.1152/ajpcell.00045.2007.
  • Yuen, N., S.E. Anderson, N. Glaser, D.J. Tancredi and M.E. O’Donnell (2008). Cerebral blood flow and cerebral edema in rats with diabetic ketoacidosis. Diabetes 57: 1-7 2588-2594. PMCID: PMC2551666.
  • O’Donnell, M.E. Ion Transport (2008). In: A. Kastin and W Pan, eds., Understanding the Blood-Brain Barrier: The Regulatory Gatekeeper Between Brain and Body, Henry Stewart Talks Ltd., London, online publication.
  • M.E. O’Donnell (2009). Ion and water transport across the blood-brain barrier. In: F.J. Alvarez-Leefmans and E. Delpire, eds, Physiology and Pathophysiology of Chloride Transporters and Channels in the Nervous System: From Molecular to Diseases. Elsevier-Academic Press, San Diego, CA, pp 585-606.
  • Lam, T.I., P.M. Wise and M.E. O’Donnell (2009). Cerebral microvascular endothelial cell Na/H exchange: evidence for the presence of NHE1 and NHE2 isoforms and regulation by arginine vasopressin, Am. J. Physiol. Cell Physiol. 297: C278-C289. PMCID: PMC2724093.
  • Neuwelt, E.A., B. Bauer, C. Fahlke, G. Fricker, C. Iadecola, D. Janigro, L. Leybaert, Z. Molnar, M. O’Donnell, J. Povlishock, N. Saunders, F. Sharp, D. Stanimirovic, R. Watts and L. Drewes (2011). Engaging Neuroscience to Advance Translational Research in Brain Barrier Biology. Nature Reviews Neuroscience 12: 169-182. PMCID: PMC3335275.
  • Rutkowsky, J.M., B.K. Wallace, P.M. Wise and M.E. O’Donnell (2011). Effects of estradiol on ischemic factor-induced astrocyte swelling and AQP4 protein abundance. American Journal of Physiology Cell Physiology 301: C204-C212. PMCID:PMC3129821.
  • Wallace, B.K., S. Foroutan and M.E. O’Donnell (2011). Ischemia-Induced stimulation of Na-K-Cl Cotransport in cerebral microvascular endothelial cells involves AMP kinase, American Journal of Physiology Cell Physiology 301:C316-26 PMCID:PMC3154550.
  • Chen, Y.-J., G. Raman, S. Bedendiek, M.E. O’Donnell and H. Wulff (2011). The KCa3.1 blocker TRAM-34 reduces infarction and neurological deficit in a rat model of ischemia/reperfusion stroke, Journal of Cerebral Blood Flow and Metabolism 31:2363-2374 PMCID: PMC3323185.
  • Wallace, B.K., K. Jelks and M.E. O’Donnell (2012). Ischemia-Induced stimulation of Na-K-Cl Cotransport in cerebral microvascular endothelial cells: role of p38 and JNK MAP kinases, American Journal of Physiology Cell Physiology, 302: C505-C517 doi: 10.1152/ajpcell. 00261.2011. PMCID: PMC3287160.
  • Glaser, N., S. Anderson, W. Leong, D. Tancredi and M.O’Donnell (2012). Cognitive dysfunction associated with diabetic ketoacidosis in rats. Neuroscience Letters 510: 110-114. PMCID: PMC3291100.
  • Glaser, N., C. Ngo, S. Anderson, N. Yuen, A. Trifu and M. O’Donnell (2012). Effects of hyperglycemia and ketosis on cerebral perfusion, cerebral water distribution and cerebral metabolism. Diabetes 61: 1831-1837. PMCID: PMC3379676.
  • O’Donnell, M.E., Y.-J. Chen, T.I. Lam, K.C. Taylor, J. Walton and S.E. Anderson (2013) Intravenous HOE-642 reduces brain edema and Na uptake in the rat middle cerebral artery occlusion model of stroke: evidence for participation of the blood-brain barrier Na/H exchanger, Journal of Cerebral Blood Flow and Metabolism 33: 225-234  PMID:  23149557.  PMCID: PMC3564192

  • Glaser, N., S. Anderson, W. Leong, D. Tancredi and M. O’Donnell (2013)  Cognitive dysfunction associated with diabetic ketoacidosis in rats.  Neuroscience Letters 510: 110-114, 2013  PMCID: PMC3291100.

  • Glaser, N., A. Bundros, S. Anderson, D. Tancredi, W. Lo, M. Orgain and M. O’Donnell (2014)  Brain swelling during hypocapnia increases with hyperglycemia or ketosis. Pediatric Diabetes PMID: 24443981 PMCID: PMC4104267.

  • Yuen, N.,  T.I. Lam, B.K. Wallace, N.R. Klug, S.E. Anderson and M.E. O’Donnell (2014) Ischemic factor-induced increases in cerebral microvascular endothelial cell Na/H exchange activity and abundance: evidence for involvement of ERK1/2 MAP kinase.  American Journal of Physiology Cell Physiology 306: C931-C942. PMID: 245647544 PMCID: PMC4024711.

  • Lo, W., M.E. O’Donnell, D. Tancredi, M. Orgain and N. Glaser (2014)  Diabetic ketoacidosis in juvenile rats is associated with reactive gliosis and activation of microglia in the hippocampus.  Pediatric Diabetes 15: 484-493. doi: 10.1111/pedi.12251 PMID: 25594864.

  • O’Donnell, M.E.  Blood Brain Barrier Na Transporters in Ischemic Stroke (2014) In: T.P. Davis, ed., Advances in Pharmacology, “Pharmacology of the blood brain barrier: targeting CNS disorders, 71,  Burlington: Academic Press, pp 113-146. Doi: 10.1016/bs.apha.2014.06.11. Epub 2014 Aug 23. PMID: 25307215  PMID 25407215 [PubMed – in process].

  • Glaser, N., W. Lo, D. Tancredi, M. Orgain, V. Puvenna, D. Janigro and M. O’Donnell (2015) Reduced levels of S100B in both brain and blood of rats with diabetic ketoacidosis. Brain Research: in press. DOI: http://dx.doi.org/10.1016/j.brainres.2015.07.044

  • Chen, Y.-J., B.K. Wallace, N. Yuen, D.P. Jenkins, H. Wulff and M.E. O’Donnell (2015)  Blood brain barrier KCa3.1 channels: evidence for a role in brain Na uptake and edema in ischemic stroke.  Stroke 46: 237-244 PMID 25477223 PMCID: PMC4276511

  • M.E. O’Donnell (2015)  The neurovascular unit. In: The Blood-Brain Barrier in Health and Disease: Moprhology, Biology and Immune Function, Volume 1 K. Dorovini-Zis, ed. CRC Press, Taylor & Francis Group, Chapter 4, pp 86-118. http://www.crcpress.com/product/isbn/9781498727051