Alan Conley

image of Alan Conley

Professor of Population Health and Reproduction

Departments

Vet Med - Population Health and Reproduction
Vet Med - Population Health and Reproduction

Offices and Labs

1114 Tupper Hall
752-1358

Profile Introduction

Biochemical and molecular control of gonadal and adrenal steroidogenesis and its role in the reproductive development and physiology of vertebrates

Degrees

1988 PhD Iowa State University
1986 MS Iowa State University
1977 BVSc Veterinary Medicine & Surgery University of Melbourne

Research Interests

Biochemical and molecular control of gonadal and adrenal steroidogenesis and its role in the reproductive development and physiology of vertebrates

Awards

Chancellor's Fellow 2002-2007
Pfizer Award for Research Excellence, School of Veterinary Medicine, University of California-Davis, 2006
Favorite Teacher Award 2007, School of Veterinary Medicine (Class of 2009)

ProfessionalSocieties

Endocrine Society
Society for the Study of Reproduction

CBS Grad Group Affiliations

Molecular, Cellular, and Integrative Physiology

Specialties / Focus

Molecular, Cellular, and Integrative Physiology
  • Endocrinology
  • Domestic Animal Physiology

Graduate Groups not Housed in CBS

Animal Biology
Comparative Pathology

Labs

Conley
  • Jo Corbin (laboratory manager)

Teaching Interests

Comparative reproductive development and function of vertebrate species.

Courses

PGG 220 General and Comparative Physiology of Reproduction (FALL)
Repro VMD 446 Veterinary Reproduction (WINTER)
VMD 446 Veterinary Reproduction (WINTER)

Publications

5/21/2010 9:26:34 AM
  • Corbin CJ, Trant JM, Walters KW, Conley AJ. 1999. Changes in testosterone metabolism associated with the evolution of placental and gonadal isozymes of porcine aromatase cytochrome P450. Endocrinology. 140:5202-5210
  • Mapes S, Corbin CJ, Tarantal A, Conley A. 1999. The primate adrenal zona reticularis is defined by expression of cytochrome b5, P450c17 and reductase but not 3beta-HSD. J Clin Endocrinol Metab 84:3382-3386
  • Conley AJ, Elf P, Corbin CJ, Dubowsky S, Fivizzani A, Lang JW. 1997. Yolk steroids decline during sexual differentiation in the alligator. General and Comparative Endocrinology. 107:191-200
  • Conley, A. J. and M. M. Hinshelwood. 2001. Mammalian aromatases. Reproduction. 121:685-695
  • Mapes, S., A. F. Tarantal, C. R. Parker, F. M. Moran, J. M. Bahr, L. Pyter and A. J. Conley. 2002. Adrenocortical cytochrome b5 expression during fetal development of the rhesus macaque. Endocrinology 143:1451-1458
  • Conley, A. J., S. M. Mapes, C. J. Corbin, D. Greger and S. Graham. 2002. Structural determinants of aromatase cytochrome P450 inhibition in substrate recognition site (SRS)-1. Molecular Endocrinology 16:1456-1468
  • Corbin, C. J., S. M. Mapes, J. Marcos, C. H. Shackleton, D. Morrow, S. Safe, T. Wise, J. J. Ford and A. J. Conley. 2004. Porcine paralogues of aromatase cytochome P450: A novel hydroxylase activity is associated with the survival of a duplicated gene. Endocrinology 145:2157-2164
  • Conley, A. J., J. C. Pattison and I. M. Bird. 2004. Variations in adrenal androgen production in (non-human) primates. Seminars in Reproductive Medicine 22:311-326
  • Vidal, J. D., C.A. VandeVoort, C. B. Marcus, N.R. Lazarewicz and A.J. Conley. 2005. 2,3,7,8-tetrachlorodibenzo-p-dioxin induces CYP1B1 expression in human luteinized granulosa cells. Archives of Biochemistry and Biophysics 439:53-60
  • Johnson, D. L., A. J. Conley and L. L. Martin. 2006. Direct electrochemistry of human, bovine and porcine cytochrome P450c17. Journal of Molecular Endocrinology 36:349-359
  • Schuler, G., G. R. Oezalp, B. Hoffmann, N. Harada, P. Browne and A. J. Conley. 2006. Reciprocal expression of 17alpha-hydroxylase/C17,20-lyase (P450c17) and aromatase (P450arom) cytochromes P450 during bovine trophoblast differentiation: A two-cell system drives placental estrogen synthesis. Reproduction 131:669-679
  • Browne, P., A. J. Conley, T. Spraker, R. R. Ream and B. L. Lasley. 2006. Sex steroid concentrations and localization of steroidogenic enzyme expression in free-ranging female northern fur seals (Callorhinus ursinus). General and Comparative Endocrinology 147:175-83
  • Browne, P., N. J. Place, J. D. Vidal, I. Moore, G. R. Cunha, S. E. Glickman and A. J. Conley. 2006. Endocrine differentiation of fetal ovaries and testes of the spotted hyena (Crocuta crocuta): Timing of androgen-independent versus androgen-driven genital development. Reproduction 132:649-659
  • Glickman, S. E., G. R. Cunha, C. M. Drea, A. J. Conley and N. J. Place. 2006. Mammalian sexual differentiation: lessons from the spotted hyena. Trends in Endocrinology and Metabolism 17:349-356
  • Corbin, C.J., A. L. Hughes, J. R. Heffelfinger, T. Berger, T. B. Waltzek, J. F. Roser, T. C. Santos, M. A. Miglino, M. F. Oliveira, F. C. Braga, F. V. Meirelles and A. J. Conley. 2007. Evolution of suiform aromatases: ancestral duplication with conservation of tissue-specific expression in the collared peccary (Pecari tayassu). Journal of Molecular Evolution 65:403-12
  • Conley, A. J., C. J. Corbin and A. L. Hughes. 2008. Adaptive evolution of mammalian aromatases: Lessons from Suiformes. Journal of Experimental Zoology 309A:1-12
  • Nguyen, A. D., S. M. Mapes, C. J. Corbin and A. J. Conley. 2008. Morphological adrenarche in rhesus macaques: Zona reticularis development is concurrent with foetal zone regression in the early neonatal period. Journal of Endocrinology 199:367-78
  • Nguyen, A. D., C. J. Corbin, J. C. Pattison, I. M. Bird and A. J. Conley. 2009. The developmental increase in adrenocortical 17,20-lyase activity (biochemical adrenarche) is driven primarily by increasing cytochrome b5 in neonatal rhesus macaques. Endocrinology 150:1748-56
  • Corbin, C. J., T. Berger, J. J. Ford, C. E. Roselli, W. Sienkiewicz, B. Trainor, J. F. Roser, J. D. Vidal, N. Harada and A. J. Conley. 2009. Porcine brain aromatase cytochrome P450: isoform characterization, sexually dimorphic and regional expression, and regulation by enzyme inhibition in neonatal boars. Biology of Reproduction 81 388-395
  • Praporski, S., S. M. Ng, A. D. Nguyen, C. J. Corbin, A. Mechler, J. Zheng, A. J. Conley and L. L. Martin. 2009. Organization of enzymes involved in sex steroid synthesis: Protein-protein interactions in lipid membranes. Journal of Biological Chemistry 284: 33224-33232
  • Brömel, C., E. C. Feldman, A. P. Davidson, R. W. Nelson, P. H. Kass, A. E. Vico, P. Labelle, C. J. Munro and A. J. Conley. 2009. Serum 17α-hydroxyprogesterone concentrations during the reproductive cycle in healthy dogs and in dogs with hyperadrenocorticism. Journal of the American Veterinary Medical Association (accepted)