Thomas Jue

image of Thomas Jue

Professor of Biochemistry and Molecular Medicine


Biochemistry and Molecular Medicine

Offices and Labs

4323 Tupper Hall

Profile Introduction

Nuclear magnetic resonance spectroscopic/imaging techniques to observe the regulation of intermediary metabolism


1983 PhD Chemistry University of California, Davis

Research Interests

Handbook of Modern Biophysics

Book series in modern biophysics

Nuclear magnetic resonance spectroscopy/imaging, molecular diffusion in the cell, structure-function of protein in the cell, apolipoprotein function/regulation, intermediary metabolism, theory of respiratory control, signal transduction and metabolism linkage in cancer, tumor biomarkers, physiological adaptation in diving mammals, comparative physiology.

CBS Grad Group Affiliations


Specialties / Focus

Exercise Science
  • Exercise Physiology

Graduate Groups not Housed in CBS

Graduate Group in Nutrition
Biomedical Engineering Graduate Group

Teaching Interests

Biomedical NMR and metabolic regulation.


10/19/2017 11:10:06 AM
  • Bendahan, D., Chatel, B, and Jue, T.  Comparative NMR and NIRS analysis of oxygen dependent metabolism in exercising finger flexor muscles, 2017  Am. J. Physiology  DOI: 10.1152/ajpregu.00203.2017

  • Jue, T., Shih, L., Chung, Y., Differential interaction of myoglobin with select fatty acids of carbon chain lenghts C8 to C16, Lipids, 2017. DOI 10.1007/s11745-017-4272-z

  • Jue, T., Simond, G., Wright, T. J., Shih, L., Chung, Y., Sriram, R., Kreutzer, U., and Davis, R., Effect of fatty acid interaction on Mb oxygen affinity and triglyceride metabolism, J. Physiol. & Biochem, 2017.  doi:10.1007/s13105-017-0559-z

  • Masuda, K., Jue, T., Hamidie, R.D.R., Mitochondrial biogenesis induced by exercises and nutrients:  Implication for performance and health benefits, Indonesian J of Sci & Tech, 2, 99-107, 2017.  DOI:

  • Takakura, H., Ojino, M., Jue, T., Yamada, T., Furuichi, Y., Hashimoto, T., Iwase, S., Masuda, K., Intracellular oxygen tension limits muscle contraction-induced change in muscle oxygen consumption under hypoxic conditions during Hb-free perfusion, 2016. Physiiological Reports, doi: 10.14814/phy2.13112

  • Yamada, T., Takakura, H., Jue, T. Hashimoto, T. Ishizawa, R. Furuichi, Y. Kato, Y., Iwanaka, N. Masuda, K.  Myoglobin and the regulation of mitochondrial respiratory chain complex IV.  J. Physiol., 594, 483-495, 2016.  doi: 10.1113/JP270824.

  • Shih, L., Chung, Y., Sriram, R., and Jue, T. Interaction of myoglobin with oleic acid. Chem & Physics of Lipids, Chem Phys Lipids, 191, 115-122, 2015. doi: 10.1016/j.chemphyslip.2015.07.010.

  • Park, J.M., Josan, S., Mayer, D., Hurd, R. E., Chung, Y.,  Bendahan, D.,  Spielman, D. M., and Jue, T., Hyperpolarized 13C NMR Observation of Lactate Kinetics in Skeletal Muscle, J Exp Biol, 18,3308-3318,2015. DOI: 10.1113/JP270824.

  • Jue, T., Measuring Intracellular Oxygenation with the Myoglobin Signals, Encyclopedia of Magnetic Resonance, ed by John Griffiths and Paul Bottomley, John Wiley & Sons,  4, 635-642,  2015. DOI: 10.1002/9780470034590.emrstm1452.

  • Takakura, H., Furuichi,Y.Yamada, T., Jue, T., Ojino, M., Hashimoto, T., Iwase, S., Hojo, T., Izawa, T.,  Masuda, K., Endurance training facilitates myoglobin desaturation during muscle contraction in rat skeletal muscle, Scientific Report, 5, 9403, 1-6, 2014. doi:10.1038/srep09403.

  • Shih, L., Chung, Y., Sriram, R., and Jue, T., Palmitate Interaction with Physiological States of Myoglobin. Bioch BiophyActa, 1840, 656-666, 2014.  DOI: 10.1016/j.bbagen.2013.10.028.

  • Masuda, K., Yamada, T., and Jue, T. Reply to Pancheva, Pancheva, Pancheva, J. Appl. Physiol., 115, 1, 151, 2013.  doi: 10.1152/japplphysiol.00449.2013.

  • Lagerstedt, J.O., Petrlova, J., Hilt, S., Marek, A., Chung, Y., Sriram, Budamagunta, M.S.,  Desreux, J. F., Thonon, D., Jue, T., Smirnov, A.I., Voss, J. C.,  EPR assessment of protein sites for incorporation of Gd(III) MRI contrast labels, Contrast Media & Molecular Imaging, 8, 252-264, 2013.  doi: 10.1002/cmmi.1518.

  • Yamada, T. Yasuro, F., Hisashi, T., Hashimoto, T. Hanai, Y., Jue, T, and Masuda, K.,   Interaction between myoglobin and mitochondria in rat skeletal muscle, J. Appl. Physiol., 114(4):490-7, 2013.  doi: 10.1152/japplphysiol.00789.2012.

  • Sriram, R. Lagerstedt, J.O., Petrolova, J., Samardzic, H. Kreutzer, U., Xie, Hongtao, Kaysen, G. A., Desreux, J.F., Thonon, D. F., Jacques, V., Van Loan, M., Rutledge, J. C., Oda, M. N., Voss, J. C., and Jue, T. Imaging apolipoprotein AI in vivo. NMR in Biomedicine, 24, 926-024,2011. DOI: 10.1002/nbm.1650.

  • Tomita, A., Kreutzer, U., Adachi, S., Koshihara, SY, and Jue, T. "It’s Hollow“: the function of pores within myoglobin. J. Exp. Biol. 213: 2748-2754, 2010.
  • Gros, G., Wittenberg, BA, and Jue, T. Myoglobin’s old and new clothes: form molecular structure to function in living cells. J. Exp. Biol. 213: 2713-2725, 2010.
  • Takakura, H., Masuda, K., Hashimoto, T., Iwase, S., and Jue, T. Quantification of Myoglobin Deoxygenation and Intracellular PO2 during Muscle Contraction under Hb-free Medium Perfusion, Exp Physiology, 95, 630-640, 2010.
  • Xie, H., Kreutzer, U., and Jue, T., Oximetry with the NMR Signal of Hemoglobin Val E11, Eur. J. Appl. Physiol., 107,325-333, 2009
  • Masuda, K., Takakura, H, Furuichi , H., Iwase, S., and Jue, T. NIRS Measurement of O2 Dynamics in Contracting Blood and Buffer Perfused Hindlimb Muscle, Adv. Experimental Med., 662: 323-328, 2009
  • Sriram, R., Kreutzer, U., Shih, L-F., and Jue, T. Interaction of Fatty Acid with Myoglobin, FEBS Letter, 582, 3643-3549, 2008.
  • Ponganis, P.J., Kreutzer, U., Stockard, T., Lin, P.C., Sailasuta, N., Tran, T.K., Hurd,R., and Jue, T. Blood Flow and Metabolic Regulation in Seal Muscle During Apnea, J. Exp. Biol., 211, 3323-3332, 2008
  • Masuda, K., Truscott, K., Lin, P-Chang, Kreutzer, U., Chung, Y., Sriram, R., and Jue, T. Determination of Myoglobin Concentration in Blood Perfused Mouse Myocardium, Eur. J. Appl. Physiol., 104, 41-48, 2008.
  • Lin, P.C., Kreutzer, U., and Jue, T. Mb Translational Diffusion in Myocardium and Its Implication on Intracellular Oxygen Transport, J. Physiol, 578, 595-603, 2007.
  • Lin, P.C., Kreutzer, U., and Jue, T. Anisotropy and Temperature Dependence of Mb Translational Diffusion in Myocardium: Implication on Oxygen Transport and Cellular Architecture, Biophysical J. 92: 2608-2620,2007.
  • Jue, T. A voice over the smoke for academic freedom. Science, 315(5814): 937, 2007.
  • Kreutzer, U. and Jue, T. Investigation of Bioactive NO Scavenging Role of Mb in Myocardium, Eur. J. Physiol. 452, 36-42, 2006.
  • Chung, Y., Huang, S.-J., Glabe, A., and Jue, T. Implication of CO inactivation on myoglobin function, Am. J. Physiol., 290, C1616-C1624, 2006.
  • Chung, Y. Mole, P.A., Sailasuta, N., Tran, T. K., Hurd, R. Control of respiration and bioenergetics during a muscle contraction. Am. J. Physiol. 288, C730-738, 2005.