Jerold Last

Professor of Pulmonary, Critical Care, and Sleep Medicine


Pulmonary (Internal Medicine)

Offices and Labs

6519 GBSF


1965 PhD Ohio State University
1961 MS Biochemistry University of Wisconsin
1959 BS Chemistry University of Wisconsin

Research Interests

Lung Biochemistry: Asthma, Air Pollution, and Lung Fibrosis

We study lung biochemistry and inflammation in mouse models of asthma and in mice exposed to particulate air pollutants.  I also have a long-standing interest in changes in lung collagen accompanying fibrotic lung diseases in animal models and human tissue.


Fulbright Scholar, Uruguay (1982 and 1999), Argentina (1999)
Frank R. Blood Award, Society of Toxicology
ICI/Zeneca Traveling Scholar Award, Society of Toxicology
School of Medicine: Faculty Research Award and Joan Oettinger Memorial Research Award
UCD Distinguished Public Service Award, 2003
Gaspar de Portola Lectureship, Barcelona, 2000

Department and Center Affiliations

Center for Comparative Respiratory Biology and Medicine


Society of Toxicology

CBS Grad Group Affiliations

Biochemistry, Molecular, Cellular and Developmental Biology

Specialties / Focus

Biochemistry, Molecular, Cellular and Developmental Biology
  • Biochemistry
  • Cellular Responses to Toxins and Stress
  • Genomics, Proteomics and Metabolomics
  • Molecular Medicine

Graduate Groups not Housed in CBS

Pharmacology and Toxicology


6519 Genomics Building website
  • Lisa Franzi, Angela Linderholm

Field Sites

National University of Argentina, Salta
Universidad de la Republica, Montevideo, Uruguay

Teaching Interests

Biochemistry, Medicine, Toxicology

Personal Interests

South America


10/21/2015 11:36:31 AM
  • Williams KM, Franzi LM, Last JA. Cell-specific oxidative stress and cytotoxicity after wildfire coarse particulate matter instillation into mouse lung. Toxicol Appl Pharmacol. 2013 Jan 1; 266(1):48-55.

  • Morel, N, Lassabe G, Elola S, Herrera S, Mari C, Last JA, Jensen O, Gozalez-Sapienza G.  (2013) A Monoclonal Antibody-Based Copro-ELISA Kit for Canine Echinococcosis to Support the PAHO Effort for Hydatid Disease Control in South America. PLOS Neglected Tropical Diseases, 7(1): e1967. doi:10.1371/journal.pntd.0001967.

  • Rossotti M, Carlomagno, M, Gonzalez-Techera A, Hammock B, Last, J, Gonzalez-Sapienza, G. (2010) Phage Anti-Immunocomplex Assay (PHAIA) for clomazone: Two-site recognition increases assay specificity and facilitates adaptation into a rapid on-site format. Analytical Chemistry, 82(21):8838-8843.

  • Carlomagno M, Matho C, Cantou, G, Sanborn J, Last J, Hammock B, Roel A, Gonzalez D, Gonzalez-Sapienza, G. (2010) A Clomazone Immunoassay to Study the Environmental Fate of the Herbicide in Rice (Oryza sativa) Agriculture. Journal of Agricultural and Food Chemistry 58:4367-4371. PMID: 20302341
  • Zeki AA, Bratt JM, Rabowsky M, Last JA, Kenyon NJ. (2010) Simvastatin Inhibits Goblet Cell Hyperplasia and Lung Arginase in a Mouse Model of Allergic Asthma: A Novel Treatment for Airway Remodeling? Translational Research,156:335-349.
  • Bratt JM, Franzi LM, Linderholm AL, O’Roark EM, Kenyon NJ, Last JA. Arginase Inhibition in Airways from Normal and Nitric Oxide Synthase 2-Knockout Mice Exposed to Ovalbumin. Toxicol. Appl. Pharmacol. 2010, 242:1-8. PMID: 19800904
  • Zeki AA, Franzi L, Last J, Kenyon NJ. (2009) Simvastatin Inhibits Airway Hyperreactivity: Implications for the Mevalonate Pathway and Beyond. Am J Respir Crit Care Med 180:731-740.
  • González-Techera A., Vanrell L., Last J.A., Hammock B.D., and González-Sapienza G. (2007) Phage Anti-Immune Complex Assay: General Strategy for Noncompetitive Immunodetection of Small Molecules. Anal Chem. 79:7799-7806. PMID: 17845007
  • Armstrong, L.C. and Last, J.A.. (1995). Rat lysyl hydroxylase: molecular cloning, mRNA distribution, and expression in a baculovirus system. Biochimica et Biophysica Acta. 1264:93-102