Robert H Weiss

image of Robert H Weiss



Chief of Nephrology, Sacramento VA Medical Center
Internal Medicine (Nephrology), School of Medicine

Offices and Labs

GBSF rm 6311
(530) 752-4010

Profile Introduction

cyclins and cyclin inhibitors, kidney cancer growth control, metabolomics and proteomics, polycystic kidney disease, other kidney diseases


1991 Fellowship, Nephrology University of California, San Francisco
1984 MD Medicine University of California, Irvine
1980 MS Medical Physics University of California, Los Angeles
1978 MS Physical Chemistry University of California, Los Angeles
1976 BA Chemistry University of California, Santa Cruz

Research Interests

cyclins and cyclin inhibitors, cancer growth control, metabolomics and proteomics, polycystic kidney disease

Department and Center Affiliations

UC Davis Cancer Center

CBS Grad Group Affiliations

Integrative Genetics and Genomics
Biochemistry, Molecular, Cellular and Developmental Biology

Graduate Groups not Housed in CBS

Immunology Comparative Pathology
Comparative Pathology Graduate


2/3/2015 9:15:34 AM
    1. Taylor, S.L., Ganti, S., Bukanov N.O., Chapman, A., Fiehn, O., Osier, M., Kim, K., Weiss, R.H. A metabolomics approach using juvenile cystic mice to identify urinary biomarkers and altered pathways in polycystic kidney disease, American Journal of Physiology: Renal Physiology, 2010, 298:909-922, with Editorial Forum
  • Chen H, Li C, Huang J, Cung T, Seiss K, Beamon J, Carrington MF, Porter, LC, Burke PS, Yang Y, Ryan BJ, Liu R, Weiss RH, Pereyra F, Cress WD, Brass AL, Rosenberg ES, Walker BD, Yu XG, Lichterfeld M. CD4+ T cells from elite controllers resist HIV-1 infection by selective upregulation of p21 (cip-1/waf-1).  Journal of Clinical Investigation. Apr 1;121(4):1549-60, 2011

    1. Weiss R.H, Kim K. Metabolomics in the Study of Kidney Diseases. Nature Reviews Nephrology. Oct 25;8(1):22-33, 2011
    1. Ganti, S., Taylor,S.L., Aboud,O.A., Yang,J., Evans,C., Osier,M.V., Alexander,D.C., Kim,K., Weiss,R.H. Simultaneous multiple matrix metabolomics analysis of a mouse kidney cancer xenograft yields potential tumor biomarkers. Cancer Research, Jul 15;72(14):3471-9, 2012
    1. Abu Aboud, A., Wettersten, H., Weiss, R.H. Inhibition of PPAR<alpha> induces cell cycle arrest and apoptosis, and synergizes with glycolysis inhibition in kidney cancer cells, 2013, PLoS ONE, Aug 7;8(8):e71115
    1. Kim, K.,Mall, C., Taylor, S.L., Hitchcock, S., Zhang, C., Wettersten, H.I., Jones, A.D., Chapman, A., Weiss, R.H., Mealtime, temporal, and daily variability of the human urinary and plasma metabolomes in a tightly controlled environment, 2013, PLoS ONE, Jan 24;9(1):e86223
  • Gupta, R., Dong, Y., Wettersten, H.I., Chang, C., Min, J., Henson, J.,  Solomon, P. , Dogra,S., Hwang,. S.H., Hammock, B.D., Reddel, R., Zhu, L., Saltzman, W., Weiss, R.H., Chang, S., Green, M., Wajapeyee, N. Synergistic tumor suppression by combined inhibition of telomerase and CDKN1A. Proceedings of the National Academy of Sciences (USA), 2014 Jul 29;111(30):E3062-E3071

    1. Tan, M., Wettersten, H.I., Chu, K., Huso, D.L., Watnick, T., in revision, S., Landesman, Y., Weiss, R.H. Novel inhibitors of nuclear transport cause cell cycle arrest and decrease cyst growth in ADPKD associated with decreased cdk4 levels, American Journal of Physiology: Renal Physiology, 2014 Dec 1;307(11):F1179-86
    1. Wettersten HI, Kauffman M, Shacham S, Landesman Y, Weiss, R.H. Specific Inhibition of the Nuclear Exporter Exportin-1 Attenuates Kidney Cancer Growth, PLoS One, 2014, Dec 2;9(12):e113867
  • Davis BB, Thompson DA, Howard LL, Morisseau C, Hammock BD and RH Weiss. 2002. Inhibitors of soluble epoxide hydrolase attenuate vascular smooth muscle cell proliferation. Proceedings of the National Academy of Sciences (USA). 99(4):2222-2227
  • Lin, P.Y., Fosmire, S.P., Baksh, S., Modiano, J.F., Weiss, R.H. Attenuation of PTEN increases p21 stability and cytosolic localization in kidney cancer cells: a potential mechanism of apoptosis resistance, Molecular Cancer, 6:16, 2007
  • Park, S.H., Wang, X., Liu, R., Lam, K.S., Weiss, R.H. High throughput screening of a small molecule one-bead-one-compound combinatorial library to identify attenuators of p21 as chemotherapy sensitizers, Cancer Biology & Therapy, 7(12), 2015-22, 2008
  • Kim, K.M., Aronov, P.A., Zakharkin, S.O., Anderson, D., Perroud, B., Weiss, R.H., Urine metabolomic analysis for kidney cancer detection and biomarker discovery, Molecular and Cellular Proteomics, 8(3):558-70, 2009
  • Perroud, B., Ishimaru, T., Borowsky, A.D., Weiss, R.H. Grade-dependent proteomic characterization of kidney cancer, Molecular and Cellular Proteomics, May;8(5):971-85, 2009
  • Liu , J.-Y. Park, S.-H., Morisseau , C., Hwang , S. H., Hammock, B., Weiss, R.H., Sorafenib Has sEH Inhibitory Activity Which Contributes to Its Effect Profile in vivo, Molecular Cancer Therapeutics, 2009 Aug;8(8):2193-203, 2009
  • Weiss, R.H. p21Waf1/Cip1 as a therapeutic target in breast and other cancers, Cancer Cell, 4: 426-429, 2003