Tsung-Yu Chen

image of Tsung-Yu Chen

Professor, Structure, function and physiology of ion channels/transporters


Center for Neuroscience
Neurology - Medicine

Offices and Labs

1544 Newton Court, Davis, CA
1544 Newton Court, Davis, CA

Profile Introduction

Structures, functions and physiological roles of ion channels.


1994 PhD Johns Hopkins University School of Medicine
1988 MS National Yang-Ming Medical College
1986 MD National Yang-Ming Medical College

Research Interests

Structures, functions and physiological roles of ion channels and transporters.


Paul Cranefield Award, Society of General Physiologists, 2004.

Department and Center Affiliations

Center for Neuroscience and Dept of Neurology


Biophysical Society, USA
Society of General Physiologists, USA

CBS Grad Group Affiliations

Biochemistry, Molecular, Cellular and Developmental Biology
Molecular, Cellular, and Integrative Physiology

Specialties / Focus

Molecular, Cellular, and Integrative Physiology
  • Molecular Physiology
  • Cellular Physiology
Biochemistry, Molecular, Cellular and Developmental Biology
  • Molecular Medicine
  • Molecular Physiology
  • Neurobiology
  • Organelle and Membrane Biology
  • Structural Biology

Graduate Groups not Housed in CBS

Pharmacology and Toxicology (PTX)


Chen Lab website
  • Yawei Yu, Wei-Ping Yu, Ji-Peng Chen

Teaching Interests

Ion Channel physiology, Biophysics of ion channels


NSC 221 Cellular Neuroscience (Fall)


10/15/2014 3:57:47 PM
  • Yu Y., Tsai M.-F., Yu W.-P., and Chen T.-Y. (2015) Modulation of the Slow/Common Gating of CLC Channels by Intracellular Cadmium. J. Gen. Physiol. 146: 495-508.

  • Yu Y., Kuan A-S, and Chen T-Y (2014) Calcium-calmodulin does not alter the anion permeability of the mouse TMEM16A calcium-activated chloride channel. J. Gen. Physiol. 144:115-124.

  • Bennetts B, Yu Y, Chen T-Y, and Parker MW (2012) Intracellular beta-nicotinamide adenine dinucleotide inhibits the skeletal muscle ClC-1 chloride channel. J. Biol. Chen. 287: 25808-25820.

  • Richman DP, Yu Y, Lee T-T, Tseng P-Y, Yu W-P, Maselli RA, Tang C-Y and Chen T-Y (2012) Dominantly-inherited myotonia congenita resulting from a mutation that increases open probability of the muscle chloride channel CLC-1. Neuromol. Med. 14:328-337.

  • Tang C.-Y., and Chen T.-Y. (2011) Physiology and pathophysiology of CLC-1: mechanisms of a chloride channel disease, myotonia. Journal of Biomedicine and Biotechnology: Vol2011, Article ID 685328, 2011. doi:10.1155/2011/685328.

  • Zhang X.-D., Tseng P.-Y., Yu W.-P., and Chen T.-Y. (2009) Blocking pore-open mutants of CLC-0 by amphiphilic blockers. J. Gen. Physiol. 133: 43-58.
  • Zhang X.-D., and Chen T.-Y. (2009) Amphiphilic blockers punch through a mutant CLC-0 pore. J. Gen. Physiol. 133: 59-68.
  • Chen T.-Y., and Hwang, T.-C. (2008) CLC-0 and CFTR: Chloride channels evolved from transporters. Physiol. Rev. 88: 351-387.
  • Tseng P.-Y., Bennetts B., and Chen T.-Y. (2007) Cytoplasmic ATP inhibition of CLC-1 is enhanced by low pH. J. Gen. Physiol. 130: 217-221.
  • Bykova E. A., Zhang X.-D., Chen T.-Y., and Zheng J. (2006) Large movement in the C-terminus of CLC-0 chloride channel during slow gating. Nature Struct & Mol. Biol. 13: 1115-1119.
  • Chen T.-Y. (2005) Structure and function of ClC channels. Ann. Rev. Physiol. 67: 809-839.