Gino Cortopassi

image of Gino Cortopassi

Professor of Molecular Biosciences

Departments

VM Molecular Biosciences

Offices and Labs

3007 VM3B, located at 1089 Veterinary Medicine Way, Davis, CA, 95616
(530) 304-6810

Degrees

1992 Postdoctoral Research - Molecular Biology University of Southern California
1988 PhD Biochemistry University of California, Berkeley
1981 BA Biology Stanford University

Research Interests

Mitochondrial genetic disease and therapy

We study inherited mitochondrial genetic disease in terms of pathophysiological mechanism and potential therapeutics. Two main foci are mitochondrial neurodegenerative diseases, Friedreich's ataxia, and Leber's hereditary optic neuropathy. In both diseases there is an inherited mitochondrial defect that causes neurodegeneration. We study the pathophysiological mechanism using cell and animal models of the disease, RNAseq, microarray, QRTPCR, and biochemical assays. In the last 4 years we have used the genetically-based cellular defects to screen for drugs which may rescue the cellular defects and thus be relevant therapeutics. In this case the compounds need to be evaluated with respect to mechanism of pathophysiological rescue in cells and animals etc. We have a third project to understand the basis of leanness and 'healthy aging' in Shc knockout mice.

Awards

Zumberge Faculty Award 1992, USC
Pfizer Research Award, 2010

Department and Center Affiliations

VM:Molecular Biosciences
CEHS-Center for Environmental Health Sciences

ProfessionalSocieties

Society for Neuroscience

CBS Grad Group Affiliations

Integrated Genetics and Genomics
Biochemistry, Molecular, Cellular and Developmental Biology
Neuroscience
Molecular, Cellular, and Integrative Physiology

Specialties / Focus

Integrated Genetics and Genomics
  • Human Genetics and Genomics
  • Human Genetics and Genomics
Biochemistry, Molecular, Cellular and Developmental Biology
  • Genomics, Proteomics and Metabolomics
  • Molecular Medicine
Molecular, Cellular, and Integrative Physiology
  • Molecular Physiology
  • Cellular Physiology
  • Comparative Physiology
  • Metabolic Physiology

Graduate Groups not Housed in CBS

Pharmacology and Toxicology (PTX)

Labs

3rd floor VM3B building, located at 1089 Veterinary Medicine Drive, Davis, CA. website
  • Cortopassi lab: see website to know what we look like

Teaching Interests

I teach in the areas of biochemistry and molecular genetics
website

Courses

VMD 405 GI/Metabolism (Spring)

Publications

  • see our website www.Cortopassilab.com for all pubs